慢性肾功能衰竭患者血液透析前后血清Hcy、IL-10和IL-18检测的临床意义  

Clinical Significance of Detection of Serum Hcy,IL-10 and IL-18 Before and After Hemodialysis in Patients with Chronic Renal Failure

作　　者：胡亚会 杨国强[1] 刘旭华[2] HU Yahui;YANG Guoqiang;LIU Xuhua(Clinical Laboratory,Zhengzhou People's Hospital,Zhengzhou 450015,China;Organ Transplantation Center,Zhengzhou People's Hospital,Zhengzhou 450015,China)

机构地区：[1]郑州人民医院检验科,河南郑州450015 [2]郑州人民医院器官移植中心,河南郑州450015

出　　处：《临床医学工程》2020年第4期421-422,共2页Clinical Medicine & Engineering

基　　金：河南省医学科技攻关计划联合共建项目“Corin介导的proANP活化途径在终末期肾脏病发病机制中的作用”(2018020824)。

摘　　要：目的分析慢性肾功能衰竭患者在血液透析前后血清Hcy、IL-10和IL-18检测的临床意义。方法75例慢性肾功能衰竭患者在血液透析前后应用免疫分析法及酶联法检测血清Hcy、IL-10、IL-18水平,并与75名健康人的检测结果进行比较。结果慢性肾功能衰竭患者血液透析前后的血清Hcy、IL-10和IL-18水平均显著高于健康人群(P<0.01)。Pearson相关性分析显示,血清Hcy水平与血清IL-10、IL-18水平均呈显著正相关(P<0.01)。结论在血液透析前后检测慢性肾功能衰竭患者的血清Hcy、IL-10以及IL-18水平,对病情认知、疗效观察和疾病预后均具有一定的临床指导意义。Objective To analyze the clinical significance of detection of serum Hcy,IL-10 and IL-18 before and after hemodialysis in patients with chronic renal failure.Methods The levels of serum Hcy,IL-10 and IL-18 of 75 patients with chronic renal failure before and after hemodialysis were detected by immunoassay and enzyme-linked assay,and the results were compared with 75 cases of healthy people.Results The levels of Hcy,IL-10 and IL-18 in patients with chronic renal failure before and after hemodialysis were significantly higher than those in healthy people(P<0.01).Pearson correlation analysis showed that serum Hcy level was positively correlated with serum IL-10 and IL-18 levels(P<0.01).Conclusions The detection of serum Hcy,IL-10 and IL-18 before and after hemodialysis in patients with chronic renal failure has certain clinical guidance significance for disease cognition,curative effect observation and disease prognosis.

关 键 词：慢性肾功能衰竭 Hcy IL-10 IL-18 血液透析 

分 类 号：R459.5[医药卫生—治疗学]