三氧化二砷治疗急性早幼粒细胞白血病的应用与临床护理  

Application and Clinical Nursing of Arsenic Trioxide in the Treatment of Acute Promyelocytic Leukemia

作　　者：钟薇 ZHONG Wei(Department of Hematology,Benxi Central Hospital,Benxi 117000,China)

机构地区：[1]本溪市中心医院血液内科,辽宁本溪117000

出　　处：《中国医药指南》2020年第12期227-228,共2页Guide of China Medicine

摘　　要：目的探讨三氧化二砷治疗急性早幼粒细胞白血病的应用与临床护理。方法采集2015年1月至2018年12月收治的60例三氧化二砷治疗急性早幼粒细胞白血病患者随机数字表分组。常规护理组进行常规护理,个体化护理组进行个体化护理。比较效果。结果个体化护理组护理满意度100%高于常规护理组的70%,χ^2=8.103,P<0.05。护理后个体化护理组焦虑情绪评分、抑郁情绪评分和生活质量评分优于常规护理组,t分别是6.103和5.0234,P<0.05。个体化护理组白细胞峰值水平、达到完全缓解的时间优于常规护理组,个体化护理组白细胞峰值水平、达到完全缓解的时间分别是(25.56±3.21)d和(30.14±3.21)d。常规护理组白细胞峰值水平、达到完全缓解的时间分别是(30.87±3.91)d和(35.78±3.55)d,t分别是5.745、6.213,P<0.05。个体化护理组不良反应发生率低于常规护理组,χ^2=7.134,P<0.05,个体化护理组不良反应发生率一共有6例,总发生率20.00%,其中,有2例心电图改变,2例恶心呕吐以及2例肝肾功能损害。常规护理组不良反应发生率一共有12例,总发生率40.00%,其中,有4例心电图改变,4例恶心呕吐以及4例肝肾功能损害。结论三氧化二砷治疗急性早幼粒细胞白血病患者行个体化护理效果确切,可减少患者不良反应的发生,且达到完全缓解的时间更短,白细胞峰值更低,可改善患者的生活质量。Objective To investigate the application and clinical nursing of arsenic trioxide in the treatment of acute promyelocytic leukemia.Methods A random number table of 60 patients with arsenic trioxide treated acute promyelocytic leukemia treated from January 2015 to December 2018 was collected.Routine nursing group performed routine nursing,and individualized nursing group performed individualized nursing.Compare effects.Results The nursing satisfaction of the individualized nursing group was 100%higher than 70%of the conventional nursing group,χ^2=8.103,P<0.05.After nursing,the anxiety score,depression score and quality of life score of the individualized nursing group were better than those of the conventional nursing group.The peak white blood cell level and time to complete remission in the personalized care group were better than those in the conventional care group.The peak white blood cell level and time to complete remission in the personalized care group were(25.56±3.21)and(30.14±3.21)days,respectively.The peak leukocyte levels and time to complete remission in the conventional care group were(30.87±3.91)days and(35.78±3.55)days,respectively,with t being 5.745 and 6.213,P<0.05.The incidence of adverse reactions in the personalized care group was lower than that in the conventional care group,χ^2=7.134,P<0.05.There were 6 cases of adverse reactions in the personalized care group,with a total incidence of 20.00%,of which 2 had ECG changes.Nausea and vomiting,and liver and kidney function damage in 2 cases.There were 12 cases of adverse reactions in the conventional care group,with a total incidence of 40.00%.Among them,there were 4 cases of ECG changes,4 cases of nausea and vomiting,and 4 cases of liver and kidney damage.Conclusion Arsenic trioxide is effective in treating individual patients with acute promyelocytic leukemia.It can reduce the occurrence of adverse reactions,and the time to complete remission is shorter.The white blood cell peak is lower,which can improve the quality of life of patients

关 键 词：三氧化二砷 急性早幼粒细胞白血病 应用 临床护理 

分 类 号：R473.73[医药卫生—护理学]