肠道菌群与早产儿胃肠外营养相关性胆汁淤积的关联代谢机制研究  

Study on metabolic mechanism of cholestasis associated with intestinal flora and parenteral nutrition in premature infants

作　　者：杨惠红 廖聪娜 龙海清 YANG Huihong;LIAO Congna;LONG Haiqing(Fuyong People’s Hospital of Baoan District,Shenzhen 518103,China)

机构地区：[1]深圳市宝安区福永人民医院,广东深圳518103

出　　处：《现代医院》2020年第4期589-591,共3页Modern Hospitals

基　　金：深圳市宝安区科技局立项(20180328122613460)。

摘　　要：目的研究探讨肠道菌群与早产儿胃肠外营养相关性胆汁淤积(parenteral nutrition associated cholestasis,PNAC)的关联代谢机制,为早产儿PNAC的预防控制提供可靠依据。方法选择2018年9月-2019年6月在我院进行治疗的PNAC患儿37例,将其列为研究组,另选择未发生胆道淤积的患儿37例,将其列为对照组,比较分析两组患儿肠道菌群之间的差异。结果研究组患儿的大肠杆菌菌群数量为(5. 14±0. 36),乳酸杆菌的菌群数量为(7. 47±0. 39);双歧杆菌的菌群数量为(7. 12±0. 64)均低于对照组患儿的大肠杆菌菌群数量为(6. 79±0. 73),乳酸杆菌的菌群数量为(8. 62±0. 17);双歧杆菌的菌群数量为(8. 47±0. 83),差异具有显著统计学意义(P <0. 05)。相比较治疗前,研究组大肠杆菌数量明显减少,乳酸杆菌、双歧杆菌数量明显增加,差异性显著(P <0. 05)。结论肠道菌群数量与早产儿胃肠外营养相关性胆汁淤积发生率之间存在一定的负相关关系,为早产儿PANC的预防控制提供可靠依据。Objective To explore the metabolic mechanism of parenteral nutrition associated cholestasis( PNAC) in premature infants and provide reliable evidence for the prevention and control of PNAC in premature infants. Methods 37 children with PNAC treated in our hospital from September 2018 to June 2019 were selected as the study group and 37 children without cholestasis as the control group. The difference of intestinal flora between the two groups was compared and analyzed. Results The number of E. coli,Lactobacillus and Bifidobacterium in the study group was 5. 14 ± 0. 36,7. 47 ±0. 39,7. 12 ± 0. 64,respectively,lower than that in the control group( 6. 79 ± 0. 73) and 8. 62 ± 0. 17,respectively. The number of bacterial flora was 8. 47 ± 0. 83,and the difference is statistically significant( P < 0. 05). Compared with the treatment,the number of E. coli in the study group was significantly reduced,and the number of lactobacilli and bifidobacteria was significantly increased,and the difference was significant( P < 0. 05). Conclusion There is a negative correlation between the number of intestinal flora and the incidence of parenteral nutrition-related cholestasis in premature infants,which provides a reliable basis for the prevention and control of PANC in premature infants.

关 键 词：肠道菌群 胃肠外营养相关性胆汁淤积 早产儿 代谢机制 

分 类 号：R378[医药卫生—病原生物学]