基础FSH值对DOR患者高孕激素状态下促排卵疗效观察  

Clinical efficacy of basal FSH as progestin primed ovarian stimulation protocol for treating women with diminished ovarian reserve

作　　者：赵雪含 杨菁[1] 吴庚香[1] ZHAO Xuehan;YANG Jing;WU Gengxiang(Reproductive Medical Center of People’s Hospital of Wuhan University, Hubei Clinical Research Center for Assisted Reproductive and Embryonic Development, Wuhan, Hubei Province, 430060)

机构地区：[1]武汉大学人民医院生殖医学中心,湖北省辅助生殖与胚胎发育医学临床研究中心,430060

出　　处：《中国计划生育学杂志》2020年第3期394-398,共5页Chinese Journal of Family Planning

摘　　要：目的:探索高孕激素状态下促排卵(PPOS)方案中基础卵泡刺激素(bFSH)水平对卵巢储备功能减退(DOR)患者促排卵疗效的影响。方法:回顾性分析2016年6月-2017年10月本中心行IVF/ICSI助孕DOR患者328例,根据bFSH水平分为FSH正常组(bFSH<10 U/L)与FSH升高组(bFSH≥10 U/L),比较两组一般资料、促排卵治疗与胚胎实验室结局。结果:FSH升高组基础黄体生成素(bLH)(5.0±1.8)U/L较FSH正常组(2.5±1.5)U/L明显升高(P<0.001),基础雌二醇(bE2)(168.4±183.4)pmol/L较FSH正常组(231.0±228.8)pmol/L明显降低(P<0.01);绒毛膜促性腺激素(hCG)日>14mm卵泡数(2.8±1.7)个、获卵数(3.0±2.1)个低于FSH正常组(3.4±2.1,3.9±2.7)个(P<0.05);但两组成熟卵率、2PN受精率、2PN卵裂率、优胚率、可移植胚胎率、优胚数、可移植胚胎数均无差异(P>0.05);两组冻胚移植周期临床妊娠率无差异(P>0.05)。结论:PPOS方案可作为DOR患者有效促排卵方案,尤其对FSH升高患者有潜在应用价值。Objective:To explore the influence of basal FSH(bFSH)as progestin primed ovarian stimulation(PPOS)protocol for treating women with diminished ovarian reserve(DOR)on their outcomes of in vitro fertilization(IVF)or intracytoplasmic sperm injection(ICSI).Methods:The data of 328 women with DOR under PPOS from June 2016 to November 2017 were analyzed retrospectively,and these women were divided into Group A(women were given bFSH<10 IU/L)and Group B(women were given bFSH≥10 IU/L)according to the dosage of bFSH used.The baseline information,ovarian stimulation characteristics,and laboratory outcome of embryo of women in the two groups were collected and analyzed.Results:The value of bLH of women in group B was 5.0±1.8,which was significant higher than that(2.5±1.5)of women in group A(P<0.001),and the value of bE2 of women in group B 168.4±183.4,which was significant lower than that(231.0±228.8)of women in group A(P<0.01).The numbers of follicle>14mm and oocytes of women in group B on hCG day were 2.8±1.7 and 3.0±2.1,which were significant lower than those(3.4±2.1 and 3.9±2.7)of women in group A(P<0.05).However,there were no significant different in the mature egg rate,2PN fertilization rate,2PN cleavage rate,high-quality embryo rate,transplantable embryo rate,high-quality embryo number,and utilized embryo number of women between the two groups(P>0.05).There was no difference in clinical pregnancy rate in frozen embryo transfer of women between the two groups(P>0.05).Conclusion:PPOS protocol is benefit for women with DOR,especially for those women with high bFSH,which has potential application value.

关 键 词：高孕激素状态下促排卵方案 卵巢储备功能减退 控制性超促排卵 卵泡刺激素 

分 类 号：R714.8[医药卫生—妇产科学]