胎膜早破患者TIMP-2、G-CSF水平与绒毛膜羊膜炎关系探讨  

The relationship between the TIMP-2 and G-CSF levels and chorioamnionitis of women with premature rupture of membranes

作　　者：李艳 崔婧芳 綦萍 LI Yan;CUI Jingfang;QI Ping(Jiaozhou Central Hospital, Qingdao, Shangdong Province, 266300)

机构地区：[1]青岛市胶州中心医院,266300

出　　处：《中国计划生育学杂志》2020年第3期428-431,I0003,共5页Chinese Journal of Family Planning

基　　金：山东省医药卫生科技发展计划项目(2016WS0258)。

摘　　要：目的:探讨金属蛋白酶组织抑制剂-2(TIMP-2)和粒细胞集落刺激因子(G-CSF)水平与胎膜早破患绒毛膜羊膜炎的相关性。方法:选择2017年3月-2019年2月本院收治的胎膜早破患者83例(观察组)及同期健康足月妊娠产妇83例(对照组),检测两组胎膜组织中TIMP-2与G-CSF水平,根据实验室指征及临床检查将观察组分为无绒毛膜羊膜炎者(无炎症组,24例),满足绒毛膜羊膜炎实验室指征但无临床指征的亚临床绒毛膜羊膜炎者(亚炎症组,29例),满足实验室及临床指征的绒毛膜羊膜炎者为(炎症组,30例)。对比各组TIMP-2和G-CSF及与绒毛膜羊膜炎严重程度关系。结果:观察组胎膜组织中TIMP-2表达水平低于对照组,G-CSF表达水平高于对照组,且在观察组中无炎症组TIMP-2水平相对较高,G-CSF水平较低(均P<0.05)。TIMP-2水平与胎膜早破患者绒毛膜羊膜炎呈负相关(r=-0.647,P<0.05),G-CSF水平与胎膜早破患者绒毛膜羊膜炎呈正相关(r=0.657,P<0.05)。结论:检测TIMP-2、G-CSF可能为鉴别胎膜早破患者绒毛膜羊膜炎发生提供参考。Objective:To investigate the relationship between the tissue inhibitor of metalloproteinase-2(TIMP-2)and granulocyte colony stimulating factor(G-CSF)levels and chorioamnionitis of women with premature rupture of membranes.Methods:83 women with premature rupture of membranes were selected in observation group,and 83 normal healthy pregnant women with full-term delivery were included in control group from March 2017 to February 2019.The levels of TIMP-2 and G-CSF in the embryolemma tissue of women in the two groups were detected.According to the results of laboratory indications and clinical examination,the pregnant women in the observation group were further divided into 3 groups,which included group A(24 women without chorioamnionitis),group B(29 women with laboratory indications and without clinical symptoms),and group C(30 women with chorioamnionitis).The levels of TIMP-2 and G-CSF of women were compared among the four groups,and the relationship between TIMP-2 and G-CSF levels and the severity degree of chorioamnionitis of women were analyzed.Results:The expression level of TIMP-2 of women in the observation group was significant higher than that of women in the control group,but the level of G-CSF of women in the observation group was significant lower(P<0.05).In the observation group,the level of TIMP-2 in group A was the highest,but the level of TIMP-2 was the lowest.The TIMP-2 level was negative ly correlated with the rate of chorioamnionitis of women with premature rupture of membranes(r=-0.647,P<0.05),but the G-CSF level was positively correlated with the rate of chorioamnionitis of women with premature rupture of membranes(r=0.657,P<0.05).Conclusion:TIMP-2 and G-CSF levels in embryolemma tissue of women with premature rupture of membranes detection maybe provide evidence for differential diagnosing chorioamnionitis.

关 键 词：胎膜早破 绒毛膜羊膜炎 金属蛋白酶组织抑制剂-2 粒细胞集落刺激因子 诊断 

分 类 号：R714.433[医药卫生—妇产科学]