不孕患者抗β2-GPI、A-TPO、AsAb和EMAb水平及因素  

The levels of anti-β2-GPI,A-TPO,AsAb and EMAb of infertile women and its risk factors

作　　者：杨金伟 柴三明[1] 王琰[1] 王志强[1] 晏博 刘丽娟[1] 倪亚莉[1] YANG Jinwei;CHAI Sanming;WANG Yan;WANG Zhiqiang;YAN Bo;LIU Lijuan;NI Yali(Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu Province, 730050)

机构地区：[1]甘肃省妇幼保健院,兰州730050

出　　处：《中国计划生育学杂志》2020年第3期443-445,共3页Chinese Journal of Family Planning

基　　金：甘肃省自然科学基金(1506RJZA159);甘肃省科技计划资助(18YF1WA045)。

摘　　要：目的:探究不孕患者免疫抗体检出及相关影响因素。方法:收集2018年1月-2018年10月本院就诊的不孕女性患者61例为不孕组,61例正常生育史健康女性为对照组;分析两组抗β2糖蛋白I抗体(β2-GPI)、抗甲状腺过氧化物酶抗体(A-TPO)、抗精子抗体(AsAb)和抗子宫内膜抗体(EMAb)检出率以及影响因素。结果:在61例不孕组中,原发不孕18例(29.5%),继发不孕43例(70.5%);抗体阳性检出率不孕组β2-GPI(24.6%)、A-TPO(19.7%)、AsAb(23.0%)、EMAb(29.5%)均高于对照组(P<0.05),而原发不孕患者β2-GPI(16.4%)、AsAb(14.8%)、EMAb(19.7%)阳性检出率高于继发不孕患者(P<0.05),A-TPO阳性检出率原发与继发组比较无差异。不孕组发生排卵障碍41.0%、免疫因素29.5%、盆腔炎21.3%、输卵管病变19.7%,经logistic回归分析,上述4种病因均是女性不孕的主要危险因素。结论:女性不孕与体内抗β2-GPI、A-TPO、AsAb和EMAb抗体关系密切,对免疫性不孕病因诊断具有重要临床意义,排卵障碍、免疫因素、盆腔炎与输卵管病变是导致不孕的主要因素,临床应加以重视。Objective:To explore the detection rate of immune antibodies of infertility women,and to study its related risk factors.Methods:61 infertile women were enrolled in study group from January 2018 to October 2018,and 61 healthy women with normal birth history were selected in control group.The detection rates of anti-β2-glycoprotein I(β2-GPI)antibody,anti-thyroid peroxidase antibody(A-TPOAb),anti-sperm antibody(AsAb),and endometrial antibody(EMAb)of women were compared between the two groups.And the related risk factors of infertility were analyzed.Results:In the study group,18(29.51%)women were primary infertility,43(70.49%)women were secondary infertility.The detection rates of anti-β2-GPI,A-TPOAb,AsAb,and EMAb of women in the study group were 24.6%,19.7%,23.0%,and 29.5%,respectively,which were significant higher than those of women in the control group(P<0.05).In the study group,the detection rates of anti-β2-GPI,AsAb,and EMAb of women with primary infertility were 16.4%,14.8%,and 19.7%,respectively,which were significant higher than those of women with secondary infertility(P<0.05),but the detection rate of A-TPOAb of women with primary infertility had no different to that of women with secondary infertility.In the study group,there were 41.0%women with ovulation disorders,29.5%women with immune factors,21.3%women with pelvic inflammatory disease,and 19.7%women with fallopian tube lesions,which all were the main risk factors of infertility.Conclusion:The levels of anti-β2-GPI,A-TPOAb,AsAb,and EMAb of women has a close relationship with infertility,which has important significance for the diagnosiing immune infertility.The ovulation disorders,immune factors,pelvic inflammatory disease,and fallopian tube lesions are the main factors leading to infertility,so they should be paid more attention to in clinical practice.

关 键 词：女性不孕 免疫抗体 抗Β2糖蛋白I抗体 抗甲状腺过氧化物酶抗体 抗精子抗体 抗子宫内膜抗体 

分 类 号：R711.6[医药卫生—妇产科学]