福州地区献血人群Rh血型分布特征的调查分析  

Investigation of Rh phenotypes in Fuzhou blood donors

作　　者：张爱[1] 林洪铿[1] 何觅 佘毅敏[1] 任本春[1] ZHANG Ai;LIN Hongkeng;HE Mi;SHE Yimin;REN Benchun(Fujian Provincial Blood Center,Fuzhou,Fujian 350004,China)

机构地区：[1]福建省血液中心,福州350004

出　　处：《福建医药杂志》2020年第2期125-127,共3页Fujian Medical Journal

摘　　要：目的调查福州地区无偿献血者Rh血型各表型的分布特征,建立Rh血型献血者资料库。方法采用血型血清学方法对福州地区2010年1月至2017年12月的313 210名初次献血者进行RhD初筛,初筛阴性者再进行RhD阴性确认和表型检测;抽取13 015名RhD阳性无偿献血者进行表型检测,并建立Rh血型系统表型数据库。结果 313 210名献血者确认RhD阴性1 208人,D变异型30人,RhD阴性血型抗原表型以dccee(53.56%)和dCcee(34.35%)居多,其次为dCCee(7.03%)和dccEe(3.39%),发现稀有表型dCCEE 1人;RhD阳性献血者各表型中DCCee比例最高(45.50%),其后依次为DCcEe(34.17%)、DCcee(8.89%)和DccEE(6.57%),发现DCCEE表型2人。C和E抗原阳性率在RhD阳性和阴性献血人群的分布差异有统计学意义(P<0.01)。结论福州地区无偿献血者Rh血型血清学具有多种表型,RhD阴性献血者以dccee表型为主,RhD阳性献血者以DCCee表型为主;发现Rh血型系统稀有表型dCCEE 1人,DCCEE 2人。通过研究无偿献血人群Rh血型分布,建立本地区Rh血型表型数据库,对保证合理用血及特殊血型患者的安全输血具有重要的临床意义。Objective To study the Rh phenotype distribution of blood donors in Fuzhou area and establish a database of Rh blood type donors.Methods RhD phenotype was initially screened by routine serological test.Weak RhD variants were detected by indirect anti-globulin test(IAT).Results Of 313 210 blood donors, a total of 1 208 cases were confirmed as RhD negative, 30 cases were weak D variants.The phenotype of RhD negative was given priority to dccee(53.56%) and dCcee(34.35%), followed by dCCee(7.03%) and dccEe(3.39%).The predominant phenotypes of RhD positive were DCCee(45.50%) and DCcEe(34.17%), followed by DCcee(8.89%) and DccEE(6.57%).Conclusion The Rh serological phenotype of donors in Fuzhou area was characterized by diversity, primarily phenotypes were dccee and DCCee.It has more application significance in building rare blood group bank to meet the requirement of clinic for special blood groups.

关 键 词：RHD阴性 弱D表现型 表型 RH血型系统 

分 类 号：R446[医药卫生—诊断学]