血栓弹力图常用参数与凝血因子及凝血象相关性分析  

Analysis of the correlation between the common parameters of thromboelastography and coagulation factors and coagulation image

作　　者：陈静 洪燕英[1] 童新元[2] 丛玉隆[3] CHEN Jing;HONG Yanying;TONG Xinyuan;CONG Yulong(Department of Clinical Laboratory,Beijing Traditional Chinese Medicine Hospital,Capital Medical University,Beijing 100010,China;Statistics Teaching and Research Office,Chinese PLA General Hospital,Beijing 100853,China;Department of Clinical Laboratory,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]首都医科大学附属北京中医医院检验科,北京100010 [2]中国人民解放军总医院统计教研室,北京100853 [3]中国人民解放军总医院检验科,北京100853

出　　处：《国际检验医学杂志》2020年第9期1082-1085,共4页International Journal of Laboratory Medicine

摘　　要：目的分析血栓弹力图常用参数凝血反应时间(R值)、凝血形成时间(K值)、凝固角(α-Angle)、最大振幅(MA)、凝血指数(CI)、血凝块力学强度(G值)与凝血因子及凝血象间的相关性。方法将2018-2019年首都医科大学附属北京中医医院血栓弹力图检测结果中R、K、α-Angle角、MA、CI、G值任一项检测结果异常样本作为研究对象,-80℃冻存同一样本血浆,待样本累计到要求数量批量行凝血因子活性检测,并查询此患者与血栓弹力图同一天检测的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)检测结果,记录数据最后进行统一分析。结果K值与α-Angle相关系数为-0.968,呈近乎负的直线相关;MA与G值的相关系数为0.995,接近直线相关。血栓弹力图6个常用参数的P值为0.000,具有多元线性回归关系。纤维蛋白原(Fig)除R值外,与其他5个参数均有相关性;Ⅷ:a、Ⅸ:a与6个参数均具有显著相关性。与APTT有显著相关性的参数为R值、K值、α-Angle和CI;TT则与MA和G值有显著相关性。对纳入研究的9个凝血因子和PT、APTT、TT进行多元线性回归分析发现,仅有Fig和APTT与6个常用参数之间存在回归关系。结论在整体衡量患者凝血状态上,血栓弹力图直观、全面;但不可通过血栓弹力图的结果来推测凝血因子和凝血象的可能结果,其之间没有必然的一一对应关系。Objective To analyze the correlation between R,K,α-Angle,MA,CI,G and coagulation factor as well as coagulation image.Methods The abnormal results of any of the six commonly used parameters of the thromboelastography of Beijing Traditional Chinese Medicine Hospital,Capital Medical University.From 2018 to 2019 as the research objects,Freeze the same sample at-80℃,after the samples are accumulated to the required quantity,coagulation factor activity can be detected in batches.The results of prethrombin time(PT),activated partial thromboplastin time(APTT)and thrombin time(TT)detected on the same day with the thromboelasmogram were also inquired and record data for unified analysis.Results The correlation coefficient between K value andα-Angle was-0.968,showed a negative linear correlation;the correlation coefficient between MA and G value was 0.995,approached a linear correlation.The P-value of six common parameters of thromboelastography was 0.000,which had multiple linear regression relationship.Fig had correlation with 5 other parameters except R value;Ⅷ:a,Ⅸ:a had significant correlation with 6 parameters.The parameters that had significant correlation with APTT are R value,K value,α-Angle and CI;TT had significant correlation with MA and G value.The multiple linear regression analysis of 9 coagulation factors and PT,APTT,TT showed that only Fig and APTT had regression relationship with 6 commonly used parameters.Conclusion In the overall measurement of the blood coagulation state,the thromboelastogram is relatively intuitive and comprehensive;however,the possible results of coagulation factors and hemogram cannot be inferred from the results of thromboelastogram,and there is no inevitable one-to-one correspondence between them.

关 键 词：血栓弹力图 凝血因子 参数 

分 类 号：R33-1[医药卫生—人体生理学] R446.1[医药卫生—基础医学]