人类冠状病毒功能性细胞受体  

Functional cell receptors for human coronavirus

作　　者：晏黎 项杰 崔天盆[3] Yan Li;Xiang Jie;Cui Tianpen(Grade 2019 Clinical Laboratory Diagnostics,School of Laboratory Medicine,Hubei University of Chinese Medicine,Wuhan 430065,China;Clinical Laboratory,Jinyintan Hospital,Wuhan 430013,China;Clinical Laboratory,Wuhan No.1 Hospital,Wuhan 430022,China)

机构地区：[1]湖北中医药大学检验学院,武汉430065 [2]武汉市金银潭医院检验科,武汉430013 [3]武汉市第一医院检验科,武汉430022

出　　处：《中华检验医学杂志》2020年第3期226-229,共4页Chinese Journal of Laboratory Medicine

摘　　要：病毒感染宿主细胞需要与其表面的受体结合。受体是影响宿主范围和种间传播的重要因素。2019年12月在湖北武汉暴发流行的不明原因肺炎,其病原体为一种新型冠状病毒,WHO将其命名为2019新型冠状病毒(2019-nCoV),研究发现血管紧张素转换酶2(ACE2)为2019-nCoV的受体。本文对已知人类冠状病毒受体及其应用作简要综述,以期为2019-nCoV的溯源、跨物种传播、流行病学分析以及抗病毒药物和疫苗的研究提供参考。Viruses infect host cells by binding to receptors on their surfaces of cells.Receptor is an important factor affecting host range and interspecific transmission.In December 2019,an outbreak of unexplained pneumonia occurred in Wuhan,Hubei province.The pathogen was a new coronavirus,named 2019 novel coronavirus(2019-nCoV)by WHO.Angiotensin-converting enzyme 2(ACE2)was found to be the receptor of 2019-nCoV.This review provides a brief overview of human coronavirus receptors and their applications,with a view to providing references for the tracing,cross-species transmission,epidemiological analysis and antiviral and vaccine studies of 2019-nCoV.

关 键 词：冠状病毒属 肽基二肽酶A 受体 细胞表面 受体 病毒 

分 类 号：R3[医药卫生—基础医学]