加强我国醛固酮标准化和肾素一致化建设  

Standardization of aldosterone and harmonization of renin in China

作　　者：周伟燕[1] 张传宝[1] 马文君[2] 蔡军[2] 陈文祥[1] Zhou Weiyan;Zhang Chuanbao;Ma Wenjun;Cai Jun;Chen Wenxiang(National Center for Clinical Laboratories,Beijing Engineering Research Center of Laboratory Medicine,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China;Peking Union Medical College,National Cardiovascular Center of Chinese Academy of Medical Sciences,Hypertension Center of Fuwai Hospital,Beijing 100037,China)

机构地区：[1]北京医院,国家老年医学中心,国家卫生健康委临床检验中心,北京市临床检验工程技术研究中心,中国医学科学院老年医学研究院,北京100730 [2]北京协和医学院,中国医学科学院国家心血管病中心,阜外医院高血压中心,北京100037

出　　处：《中华检验医学杂志》2020年第3期245-249,共5页Chinese Journal of Laboratory Medicine

基　　金：国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项(2016YFC1305600,2016YFC1305603);北京生物医药产业跨越发展T程项目(G20工程,Z161100001816043);北京市东城区优秀人才培养资助项目。

摘　　要：醛固酮和肾素是高血压诊疗中重要的检测指标。目前醛固酮检测方法主要包括免疫法和质谱法,方法内变异系数大,方法间偏差较大,且免疫法结果远高于质谱法。临床上肾素的检测主要包括直接肾素浓度和肾素活性,两者在高血压诊疗中各有优劣。醛固酮肾素不一致的检测结果给临床诊疗带来很大的困扰,急需开展标准化/一致化工作以使得各实验室检测结果具有可比性,为临床提供准确可靠的诊疗指标。我国肾素醛固酮标准化/一致化项目的启动将大大推动肾素醛固酮标准化进程,实现检验结果准确可比。Aldosterone and renin are important clinical indicators in the diagnosis and treatment of hypertension.There are two kinds of methods for aldosterone detection,including immunoassay and mass spectrometry.The coefficients of variation within the methods,as well as the deviation between methods are large.And the results of immunoassay are much higher than that of mass spectrometry.Clinically,renin tests mainly include renin concentration and renin activity,both of which have advantages and disadvantages in the diagnosis and treatment of hypertension.The disordered test results of aldosterone and renin brings great trouble to the clinical diagnosis and treatment.Standardization/consistency is urgently needed to make the test results of each laboratory more accurate and comparable.The standardization project for renin and aldosterone in China will greatly promote the standardization process in order to provide accurate and comparable clinical tests.

关 键 词：醛固酮 肾素 结果可重复性 色谱法 液相 串联质谱法 

分 类 号：R446[医药卫生—诊断学]