生物组织纤维状结构空间取向的精准表征与应用  

Accurate Characterization of Spatial Orientations of Fiber-Like Structures in Biological Tissues and Its Applications

作　　者：刘智毅 孟佳 邱建榕 韩涛[1] 王迪[1] 卓双木[2] 丁志华[1] Liu Zhiyi;Meng Jia;Qiu Jianrong;Han Tao;Wang Di;Zhuo Shuangmu;Ding Zhihua(State Key Laboratory of Modern Optical Instrumentation,College of Optical Science and Engineering,Zhejiang University,Zhejiang 310027,China;Key Laboratory of Opto-Electronic Science and Technology for Medicine of Ministry of Education,Fujian Provincial Key Laboratory of Photonics Technology,Fujian Normal University,Fuzhou,Fujian 350007,China)

机构地区：[1]浙江大学光电科学与工程学院现代光学仪器国家重点实验室,浙江杭州310027 [2]福建师范大学医学光电科学与技术教育部重点实验室福建省光子技术重点实验室,福建福州350007

出　　处：《中国激光》2020年第2期14-27,共14页Chinese Journal of Lasers

基　　金：国家重点研发计划(2017YFA0700501);国家自然科学基金(11974310,61905214,31927801);浙江省自然科学基金(LR20F050001);中央高校基本科研业务费专项资金(2019QNA5004)。

摘　　要：纤维状结构是生物组织的一种基本结构形式。疾病的发生和演化常常伴随着纤维状结构空间取向的相应变化。对生物组织内纤维状结构空间取向的定量表征方法和主要应用进行了简单综述,着重介绍了空间取向信息在几种重要疾病模型中的研究进展,包括伤口愈合、骨关节炎、乳腺癌、腹膜癌扩散、脑损伤等,并在特定的人工组织模型中探究了组织结构与功能的关系。对生物组织纤维状结构的高灵敏、高精度描述,为研究疾病的发生和演化提供了新思路和手段,有望实现特定疾病的早期诊断和病理机制的深入理解。最后,对该方法的应用前景进行了展望。Fiber-like structure is one of the basic structures found in biological tissues.The spatial orientations of fiber-like structures change with the initiation and progression of some diseases.In this study,we present a brief overview of quantitative orientation analysis methods for fiber-like structures within biological tissues and main applications of these methods.We especially focus on the research progress of spatial orientation information in important disease models,including wound healing,osteoarthritis,breast cancer,peritoneal metastasis,and brain injury.Additionally,we explore the relations between tissue structure and function via specific engineered tissues.A highly sensitive and highly accurate description of the fiber-like structures within biological tissues serves as a novel method for studying disease initiation and progression,shows potential for early disease diagnosis,and improves our understanding of the mechanisms underlying some disorders.Finally,future potential applications of the orientation analysis methods are explored.

关 键 词：医用光学 纤维状结构 空间取向 三维空间结构 骨关节炎 癌症 类脑组织 多光子成像 

分 类 号：O439[机械工程—光学工程]