光学相干层析功能成像及脑中风研究进展  

Advances in Functional Optical Coherence Tomography and Neuroimaging of Stroke

作　　者：杨珊珊[1] 姚霖 刘开元 李鹏[1] Yang Shanshan;Yao Lin;Liu Kaiyuan;Li Peng(State Key Laboratory of Modern Optical Instrumentation,College of Optical Science and Engineering,Zhejiang University,Hangzhou,Zhejiang310027,China)

机构地区：[1]浙江大学现代光学仪器国家重点实验室,光电科学与工程学院,浙江杭州310027

出　　处：《中国激光》2020年第2期187-198,共12页Chinese Journal of Lasers

基　　金：浙江省自然科学基金(LR19F050002);之江实验室重大科研项目(2018EB0ZX01);中央高校基本科研专项资金(2018FZA5003)。

摘　　要：基于光学相干层析成像(OCT)的功能成像技术得以不断发展。光学相干血流造影(OCTA)技术将血红细胞与周围组织的相对运动作为内源性的血流标记特征,通过分析OCT中空间散射信号的动态光学散射特性,提取血流运动信息。OCTA技术通过在三维空间区分动态血流区域及其周围静态组织,实现了在体、无标记、三维高分辨率的血流运动造影。光学衰减系数(OAC)算法通过分析OCT中空间散射信号随深度的衰减特性,评估组织损伤程度,准确揭示组织活性。OCTA技术和OAC算法使得对脑中风过程的在体、无标记、三维高分辨率的长期监测成为可能,包括缺血及血流再灌注过程、组织损伤及其恢复程度的实时评估。针对OCTA技术和OAC算法的发展进行了系统性回顾,并介绍了相关脑中风研究的进展,上述OCT技术在生物医学领域具有重要的应用价值。Functional imaging techniques have been continuously developed based on optical coherence tomography(OCT).OCT angiography(OCTA)technique employs the relative motion of red blood cells and surrounding tissues as the endogenous label for blood flow.By analyzing the dynamic optical scattering characteristics of spatially scattered signals in OCT,the blood flow motion information is extracted.Thus,OCTA enables an in vivo,label-free,and 3 D high-resolution blood flow imaging by distinguishing dynamic blood flow areas and surrounding static tissues in three-dimensional space.The optical attenuation coefficient(OAC)algorithm evaluates the degree of tissue damage and accurately reveals tissue activity by analyzing the attenuation characteristics of spatially scattered signals in OCT with depth.OCTA technology and OAC algorithm enable in vivo,label-free,3 D high-resolution,and long-term monitoring of stroke progression in real time,including real-time assessment of ischemia and blood flow reperfusion,and tissue damage and its degree of recovery.A systematic review is made on the development of OCTA technology and OAC algorithm,and the progress of related stroke research is further introduced.The above-mentioned OCT technology has important application value in the field of biomedicine.

关 键 词：医用光学 光学相干层析成像 光学相干血流造影 光学衰减系数 脑中风 

分 类 号：TN247[电子电信—物理电子学]