稀土上转换发光纳米材料及生物传感研究进展  

Progress in Research on Rare-Earth Upconversion Luminescent Nanomaterials and Bio-Sensing

作　　者：谢荧玲 沈博 周兵帅 刘敏[3] 费虹天 孙娇[1] 董彪[2] Xie Yingling;Shen Bo;Zhou Bingshuai;Liu Min;Fei Hongtian;Sun Jiao;Dong Biao(Department of Cell Biology,College of Basic Medical Sciences,Jilin University,Changchun,Jilin 130021,China;State Key Laboratory on Integrated Optoelectronics,College of Electronic Science and Engineering,Jilin University,Changchun,Jilin 130021,China;Department of Radiology,The First Hospital,Jilin University,Changchun,J ilin 130021,China)

机构地区：[1]吉林大学基础医学院细胞生物学系,吉林长春130021 [2]吉林大学集成光电子学国家重点实验室电子科学与工程学院,吉林长春130012 [3]吉林大学第一医院放疗科,吉林长春130021

出　　处：《中国激光》2020年第2期214-233,共20页Chinese Journal of Lasers

基　　金：国家重点研发计划(2016YFC0207101);国家自然科学基金(81602659,61775080);吉林省教育厅“十三五”科学技术项目(JJKH20190101KJ)。

摘　　要：稀土掺杂的上转换纳米发光材料(UCNP)可以将低频光子转化为高频光子,通常是近红外光激发,可见光发射,这个独特的光学性质使其具有良好的生物学应用前景。近年来,UCNP已经在成像、传感等领域取得了重要进展,本文对近年来UCNP的合成、表面修饰以及在生物检测等方面的应用进行综述,涵盖了生物检测方面的重要进展,包括基于上转换荧光的温度、离子、小分子以及生物体内的重要蛋白与核酸等检测应用。Rare earth doped upconversion nanoluminescent materials(UCNP)can convert low-frequency photons into high-frequency photons,usually near-infrared light excitation and visible light emission.This unique optical property makes it promising for biological applications.In recent years,UCNPs have made significant progress in the imaging and sensing fields.This paper reviews the important progress in synthesis,surface modification,and bioassay using UCNPs,covering important advances in biological detection,and including upconversion fluorescence-based temperature,ions,small molecules,and important proteins and nucleic acids.

关 键 词：生物光学 稀土发光 上转换发光 荧光探针 生物传感 

分 类 号：O436[机械工程—光学工程]