基于高灵敏换能器的光声显微成像技术  

Photoacoustic Microscopy Based on Highly Sensitive Ultrasound Transducer

作　　者：杨晨 焦阳[1,3] 朱鑫乐[1] 简小华 George Sergiadis 崔崤峣[1] Yang Chen;Jiao Yang;Zhu Xinle;Jian Xiaohua;George Sergiadis;Cui Yaoyao(Suzhou Institute of Biomedical Engineering and Technology,Chinese Academy of Sciences,Suzhou,Jiangsu215163,China;University of Science and Technology of China,Hefei,Anhui 230026,China;University of Chinese Academy of Sciences,Beijing 101408,China;School of Electrical and Computer Engineering,Aristotle University,Thessaloniki 54124,Greece;Institute of Biological and Medical Imaging,Helmholtz Zentrum München,München 85764,Germany)

机构地区：[1]中国科学院苏州生物医学工程技术研究所,江苏苏州215163 [2]中国科学技术大学,安徽合肥230026 [3]中国科学院大学,北京101408 [4]亚里士多德大学电子与计算机工程学院,希腊塞萨洛尼基54124 [5]亥姆霍兹慕尼黑研究中心生物与医学影像研究所,德国慕尼黑85764

出　　处：《中国激光》2020年第2期374-380,共7页Chinese Journal of Lasers

基　　金：国家重点研发计划(2018YFC0116201,2017YFC0110400);国家自然科学基金(11704397,51805529);中国科学院基金(YJKYYQQ20180031);江苏省政策引导类计划(国际科技合作)(BZ2016023)。

摘　　要：在光声显微成像中,系统的探测灵敏度是决定成像质量和探测深度的关键因素,也将进一步影响光声成像在生物医学领域中的应用范围。通过将微型放大芯片集成至换能器单元,实现信号的前置放大和输出阻抗的匹配,提高了探测灵敏度和信噪比;基于制备的原型换能器搭建了光声显微成像系统,并通过仿体和大鼠耳部血管的三维成像实验,验证了该系统进行高灵敏光声显微成像的可行性。实验结果表明:基于集成放大芯片换能器的光声显微成像技术可使光声信号的信噪比提升10 dB以上,具有应用于微弱生理、病理变化检测和定量分析的潜力。In photoacoustic microscopy(PAM),detection sensitivity is an important factor for determining imaging quality and depth,which can affect photoacoustic imaging applications in biomedical engineering.To improve the detection sensitivity and signal-to-noise ratio(SNR),a miniature amplifier was integrated close to an ultrasound transducer for front-end signal amplification and output impedance matching.An optical resolution PAM was developed based on the fabricated prototype transducer to perform 3 D imaging of phantoms and small vessels of the mouse ear.Experimental results show that the SNR is improved by over 10 dB.The proposed PAM has the potential to be used for monitoring and quantitatively analyzing weak physiological changes.

关 键 词：医用光学 探测灵敏度 光声显微成像 集成放大芯片 微血管 

分 类 号：O426[理学—声学]