基于蒙特卡罗法的组织内插光纤出射激光的传输  

Transmission of a Laser Emitted from an Interpolated Optical Fiber in Tissue Based on Monte Carlo Method

作　　者：丁乐明 戴丽娟[1] 张磊[1] 钱志余[2] Ding Leming;Dai Lijuan;Zhang Lei;Qian Zhiyu(School of Mechanical Engineering,Nantong University,Nantong,Jiangsu 226019,China;School of Automation,Nanjing University of Aeronautics and Astronautics,Nanjing,Jiangsu 210046,China)

机构地区：[1]南通大学机械工程学院,江苏南通226019 [2]南京航空航天大学自动化学院,江苏南京210046

出　　处：《中国激光》2020年第2期412-417,共6页Chinese Journal of Lasers

基　　金：国家自然科学青年基金(61405098);2017年江苏政府留学奖学金。

摘　　要：考虑到肿瘤的形状特征以及激光间质热疗时激光的传输方式为内置光源,首先建立了内插光纤的双层球体生物组织模型,然后假设光子从球体中心发射,建立了光子在组织内、球体边界及内插光纤表面的传输方式,最后采用Visual Studio软件编程,基于蒙特卡罗法对光在该组织模型中的传输进行仿真。仿真结果表明:光纤主要对光子出射端面附近的光子的运动产生影响;位于光子出射面下方的组织对光子能量的吸收大于出射面上方组织对光子能量的吸收;内层球体的半径越小,内边界的吸收值越大。与传统的蒙特卡罗方法相比,所建模型更接近于激光间质热疗的实际情况,对后续准确预估激光间质热疗的热毁损范围具有重要的实际意义。To understand characteristic of the shapes of most tumors and the laser transmission mode as an internal light source during laser interstitial therapy, a double-layered media model in the shape of sphere with an interpolated optical fiber was established. Then, the modes of the photon transmitting in the tissue, at the boundary of the sphere, and on the surface of the inserted optical fiber were set, assuming the photons were launched at the center of the model. Finally, the photon migration in the model was simulated based on the Monte Carlo(MC) method in the Visual Studio(VS) program. The simulation results show that the optical fiber primarily affects the movements of photons that are moving near the surface from which they were launched. The energy absorption by the tissue under the photon-launching surface is greater than that in the above the surface. The absorption of the inner boundary increases with decreasing inner sphere radius. Compared with the traditional MC method, this model has more similarities with a real laser interstitial thermotherapy situation, which is of considerable practical significance for predicting the thermal damage range of laser interstitial thermotherapy.

关 键 词：医用光学 生物组织 蒙特卡罗法 球体模型 激光间质热疗 

分 类 号：R318.51[医药卫生—生物医学工程]