益生菌在新型冠状病毒肺炎治疗中的前景  

Prospect of probiotics in the treatment of COVID-19

作　　者：黄绦璧 张惠芸 李龙泉 梁元 张军[1,2,3] 孙蔚明[4] 王玉平[1,2,3] Huang Tao-bi;Zhang Hui-yun;Li Long-quan;Liang Yuan;Zhang Jun;SunWei-ming;Wang Yu-ping(The First School of Clinical Medicine,Lanzhou University,Lanzhou 730000,China;Department of Gastroenterology,The First Hospital of Lanzhou University,Lanzhou 730000,China;Key Laboratory for Gastrointestinal Diseases of Gansu Province,The First Hospital of Lanzhou University,Lanzhou 730000,China;Department of Endocrinology,The First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院消化科,甘肃兰州730000 [3]兰州大学第一医院甘肃省胃肠病重点实验室,甘肃兰州730000 [4]兰州大学第一医院内分泌科,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2020年第2期76-81,88,共7页Journal of Lanzhou University（Medical Sciences）

基　　金：国家自然科学基金资助项目(81570783);国家重点研究发展计划项目(2016YFC1302201);甘肃省自然科学基金资助项目(18JR3RA366)。

摘　　要：已知肠道微生物区系在人体免疫调节及对抗病毒性肺炎中发挥重要作用,对于降低病毒感染风险和加速感染后病毒清除具有重要意义。本研究阐述了呼吸道病毒感染后肠道微生物区系的变化和肠道微生物的改变又反过来影响呼吸系统及其作用机制,也就是近年来研究逐渐深入的“肠—肺轴”,强调了贯穿于“肠—肺轴”始终的免疫作用,以及微生物制剂在抗呼吸道病毒感染中的作用及其机制,从而将益生菌用于新型冠状病毒肺炎防治的潜在作用作一展望。It is known that intestinal microflora plays an important role in human immune regulation and fighting against viral pneumonia,thus being of great significance in reducing the risk of viral infection and accelerating virus clearance after infection.In this article,we explained the changes of the intestinal microflora after virus infection of the respiratory tract,which in turn affected the respiratory system and its action mechanism.The study was also reflected the fact that the“intestinal-lung axis”theory has been deepened gradually in studies in recent years.More importantly,we emphasized the immune function throughout the“intestinallung axis”and the role and mechanism of microbial agents in the prevention and treatment of virus infection of the respiratory tract,thus presenting a prospect of the potential role of probiotics in the prevention and treatment of Corona Virus Disease 2019.

关 键 词：新型冠状病毒肺炎 呼吸道病毒感染 肠道微生物区系 免疫 益生菌 

分 类 号：R117[医药卫生—公共卫生与预防医学]