乙型病毒性肝炎患者血清HBV-LP与HBV-DNA水平表达的相关性及临床意义  

Correlation and Clinical Significance of Serum HBV-LP and HBV-DNA Levels in Patients with Hepatitis B virus

作　　者：李艳芳[1] 杨雪梅[1] 罗萍[2] 曾静[2] 骆方静 董彦君 向军英[2] LI Yan-fang;YANG Xue-mei;LUO Ping;ZENG Jing;LUO Fang-jing;DONG Yan-jun;XIANG Jun-ying(Department of Infection,First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan,610500,China;Department of Gastroenterology,Affiliated Hospital of Chengdu University,Chengdu,Sichuan,610081,China)

机构地区：[1]成都医学院第一附属医院感染科,四川成都610500 [2]成都大学附属医院消化内科,四川成都610081

出　　处：《现代生物医学进展》2020年第2期353-356,369,共5页Progress in Modern Biomedicine

基　　金：四川省教育厅科研课题重点项目(18ZA0165)。

摘　　要：目的:探讨乙型病毒性肝炎患者血清乙肝病毒外膜大蛋白(HBV-LP)与乙肝病毒脱氧核糖核酸(HBV-DNA)水平表达的相关性及临床意义。方法:选择2016年1月至2018年6月间我院收治的乙型病毒性肝炎患者148例,根据不同乙型肝炎血清标志物模式将患者分为A组18例、B组52例、C组41例、D组37例。根据不同HBV-DNA载量分为阴性组70例、低载量组21例、中载量组35例、高载量组22例。检测不同乙型肝炎血清标志物模式下HBV-LP、HBV-DNA阳性率及水平,比较不同HBV-DNA载量HBV-LP水平和肝功能指标,并分析其相关性。结果:C组、D组患者HBV-LP、HBV-DNA阳性率及水平均高于A组和B组(P<0.05),A组和B组、C组和D组患者HBV-LP、HBV-DNA阳性率及水平比较差异无统计学意义(P>0.05)。阴性组、低载量组、中载量组、高载量组天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、HBV-LP水平均呈逐渐升高的趋势,组间比较差异有统计学意义(P<0.05)。经Pearson相关性分析显示,乙型病毒性肝炎患者血清HBV-LP与HBV-DNA载量的对数值、ALT、AST呈正相关(P<0.05)。结论:乙型病毒性肝炎患者血清HBV-LP可以反映HBV复制情况,并于肝功能指标密切相关。Objective:To investigate the correlation and clinical significance of the expression of HBV epicardial large protein(HBV-LP)and HBV deoxyribonucleic acid(HBV-DNA)levels in patients with hepatitis B virus.Methods:148 patients with hepatitis B virus who were treated in our hospital from January 2016 to June 2018,according to the different serum markers of hepatitis B,the patients were divided into A group with 18 cases,B group with 52 cases,C group with 41 cases and D group with 37 cases.According to different HBV-DNA loads,the patients were divided into negative group with 70 cases,low load group with 21 cases,moderate load group with 35 cases and high load group with 22 cases.The positive rate and levels of HBV-LP and HBV-DNA in different HBV serum markers were detected.The HBV-LP levels and liver function indexes of different HBV-DNA loads were compared,and their correlation was analyzed.Results:The positive rate and levels of HBV-LP and HBV-DNA in C group and D group were higher than that in A group and B group(P<0.05).There was no significant difference in the positive rate and levels of HBV-LP and HBV-DNA between A group and B group,C group and D group(P>0.05).The levels of aspartic aminotransferase(AST),alanine aminotransferase(ALT)and HBV-LP in the negative group,the low load group,the moderate load group and the high load group all showed a tendency to increase gradually,and there was a significant difference between the groups(P<0.05).Pearson correlation analysis showed that there was a positive correlation between serum HBV-LP and pair value of HBV-DNA load,ALT and AST in patients with hepatitis B viral(P<0.05).Conclusion:Serum HBV-LP in patients with hepatitis B viral can reflect the replication of HBV,and it is closely related to liver function.

关 键 词：乙型病毒性肝炎 乙肝病毒外膜大蛋白 乙肝病毒脱氧核糖核酸 相关性 临床意义 

分 类 号：R512.62[医药卫生—内科学]