儿童胃炎Hp感染与其病理关联性分析  

Relationship between Helicobacter pylori gastritis and lymphoid follicles and intestinal metaplasia in gastric mucosa of children

作　　者：王燕妮[1] 汤勉[1] WANG Yanni;TANG Mian(The Affiliated Children's Hospital of Baoji Municipal Maternity and Child Health Hospital,Shaanxi Baoji 721000,China)

机构地区：[1]陕西省宝鸡市妇幼保健院儿童医院,陕西宝鸡721000

出　　处：《中国妇幼健康研究》2020年第3期351-354,共4页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨儿童幽门螺杆菌(Hp)胃炎与其病理(胃黏膜淋巴滤泡和肠上皮化生)的关系。方法选取2016年2月至2017年8月陕西省宝鸡市妇幼保健院儿童医院收治的儿童胃炎423例,将其分为Hp阳性组(204例)和Hp阴性组(219例),分析Hp感染与胃黏膜淋巴滤泡、肠上皮化生检出率的相关性。结果确诊Hp阳性者204例(48.23%),Hp阴性者219例(51.77%),Hp阳性组胃黏膜淋巴滤泡和肠上皮化生阳性率均高于Hp阴性组(χ^2值分别为93.513、6.564,均P<0.05)。在慢性浅表性胃窦炎、十二指肠球部溃疡、萎缩性胃炎患儿中,Hp阳性组胃黏膜淋巴滤泡阳性率均高于Hp阴性组,组间比较差异均有统计学意义(χ^2值分别为63.849、30.209、4.018,均P<0.05)。在十二指肠球部溃疡及萎缩性胃炎患儿中,Hp阳性组肠上皮化生阳性率均高于Hp阴性组,组间比较差异均有统计学意义(χ^2值分别为4.399、4.500,均P<0.05),而在慢性浅表性胃窦炎患儿中两组肠上皮化生阳性率差异无统计学意义(χ^2=2.931,P>0.05)。结论儿童胃炎中Hp阳性率较高,Hp感染是胃黏膜淋巴滤泡和肠上皮化生的重要原因。Objective To investigate relationship between Helicobacter pylori(Hp)gastritis and its pathology(lymphoid follicles and intestinal metaplasia in gastric mucosa)in children.Methods 423children with gastritis who admitted to our hospital from February 2016to August 2017were selected.204children with positive Hp result were divided into Hp positive group and 219children with Hp negative result were divided into Hp negative group.The correlation between Hp infection and detection rates of lymphoid follicles and intestinal metaplasia in gastric mucosa was analyzed.Results 204children were determined as positive Hp infection(48.23%),and 219children were determined as negative Hp infection(51.77%).The positive rates of lymphoid follicles and intestinal metaplasia in gastric mucosa of the children in Hp positive group were higher than those in Hp negative group(χ^2=93.513 and 6.564respectively,both P<0.05).In Hp positive group,the positive rates of lymphatic follicles in gastric mucosa of the children with chronic superficial antral gastritis,duodenal bulbar ulcer and atrophic gastritis were higher than those in Hp negative group,and the differences were significant(χ^2=63.849,30.209and 4.018,all P<0.05).The positive rates of intestinal metaplasia in gastric mucosa of the children with duodenal bulbar ulcer and atrophic gastritis in Hp positive group were higher than those of children in Hp negative group(χ^2=4.399and 4.500respectively,both P<0.05).While in positive rate of intestinal metaplasia in gastric mucosa of the children with chronic superficial antral gastritis there was no significant difference between the two groups(χ^2=2.931,P>0.05).Conclusion The positive detection rate of Hp is higher in children with gastritis.Hp infection is an important cause of lymphoid follicles and intestinal metaplasia in gastric mucosa.

关 键 词：幽门螺杆菌 病理 淋巴滤泡 肠上皮化生 

分 类 号：R725.7[医药卫生—儿科]