中国汉族2型糖尿病人群体质量指数与血脂谱在糖尿病肾脏病中的交互作用  

Interaction between BMI and lipid profile in diabetic kidney disease in Chinese Han population with type 2 diabetes

作　　者：虞伟慧 胡珦 陈雄[1] 周琦[1] 邓慧慧[1] 顾雪疆[1] YU Weihui;HU Xiang;CHEN Xiong;ZHOU Qi;DENG Huihui;GU Xuejiang(Department of Endocrinology,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325015,China)

机构地区：[1]温州医科大学附属第一医院内分泌科,浙江温州325015

出　　处：《温州医科大学学报》2020年第4期290-294,299,共6页Journal of Wenzhou Medical University

基　　金：国家自然科学基金资助项目(81600659);温州市公益性科技计划项目(Y20140683,Y20170047)。

摘　　要：目的:探讨中国汉族2型糖尿病人群体质量指数(BMI)与血脂谱在糖尿病肾脏病(DKD)中的交互作用。方法:收集住院2型糖尿病患者647例,包括283例DKD患者以及364例非DKD的患者。采用二分类logistic回归分析血脂谱与DKD的相关性以及BMI与血脂谱的交互作用。结果:TG(OR=1.446,95%CI:1.076~1.942,P=0.014)、nonHDL-C(OR=1.961,95%CI:1.011~3.804,P=0.046)、nonHDL-C/HDL-C(OR=1.804,95%CI:1.134~2.869,P=0.013)、TC/HDL-C(OR=2.293,95%CI:1.234~4.260,P=0.009)、TG/HDL-C(OR=1.345,95%CI:1.057~1.712,P=0.016)均与DKD显著相关(OR针对各指标的自然对数计算)。BMI与TG、non HDL-C/HDL-C、TC/HDL-C、TG/HDL-C之间的交互作用具有显著统计学意义(P值分别为0.036、0.035、0.034、0.016)。结论:中国汉族人群血浆TG、nonHDL-C、nonHDL-C/HDL-C、TC/HDL-C、TG/HDL-C均与DKD独立相关。BMI与TG、nonHDL-C/HDL-C、TC/HDL-C、TG/HDL-C之间存在交互作用。Objective: To explore the interaction between BMI and lipid profile in diabetic kidney disease(DKD) in Chinese Han population with type 2 diabetes. Methods: We recruited 647 unrelated Han Chinese participants in this study, including 283 DKD patients and 364 non-DKD patients. Binary logistic regression was applied to analyze the association between lipid profile and DKD, and the interaction between BMI and lipid profile. Results: TG(OR=1.446, 95%CI: 1.076-1.942, P=0.014), nonHDL-C(OR=1.961, 95%CI: 1.011-3.804, P=0.046), nonHDL-C/HDL-C(OR=1.804, 95%CI: 1.134-2.869, P=0.013), TC/HDL-C(OR=2.293, 95%CI: 1.234-4.260, P=0.009), TG/HDL-C(OR=1.345, 95%CI: 1.057-1.712, P=0.016) were all significantly associated with DKD, ORs were calculated for the logarithmically transformed indexes. Significant interactions between BMI and TG, nonHDL-C/HDL-C, TC/HDL-C, TG/HDL-C were detected(P values equal to 0.036, 0.035, 0.034, 0.016, respectively). Conclusion: It is indicated that TG, nonHDL-C, nonHDL-C/HDL-C, TC/HDL-C, TG/HDL-C are significant risk factors for DKD in Chinese patients with type 2 diabetes. BMI modulated the association between lipid profile and DKD in this population.

关 键 词：2型糖尿病 糖尿病肾脏病 血脂谱 体质量指数 交互作用 

分 类 号：R589.1[医药卫生—内分泌]