不同外科手术取精时机对卵胞浆内单精子注射临床结局的影响  

The effect of surgical sperm extraction timing on the clinical outcomes of intracytoplasmic sperm injection

作　　者：潘承双[1] 张欢[1] 徐芝慧[1] 金建远[1] 费前进[1] 倪吴花[1] PAN Chengshuang;ZHANG Huan;XU Zhihui;JIN Jianyuan;FEI Qianjin;NI Wuhua(Reproductive Medicine Center,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325015,China)

机构地区：[1]温州医科大学附属第一医院生殖医学中心,浙江温州325015

出　　处：《温州医科大学学报》2020年第4期295-299,共5页Journal of Wenzhou Medical University

基　　金：国家自然科学基金青年基金资助项目(81903293);浙江省自然科学基金青年基金资助项目(LQ19H040004);温州市科技计划项目(Y20180675,Y20190091)。

摘　　要：目的:探讨外科手术获取精子不同时机行卵胞浆内单精子注射(ICSI)对临床结局的影响。方法:回顾性分析839例外科手术获取精子行ICSI治疗的新鲜周期,根据手术时间分为取精当日ICSI组与次日ICSI组。比较当日ICSI组和次日ICSI组间受精率、卵裂率、优质胚胎率、种植率、临床妊娠率、流产率等结果。结果:胚胎体外培养和临床结果显示取精当日ICSI组与次日ICSI组的受精率、成熟率、卵裂率、D3优质胚胎率、种植率、临床妊娠率、流产率差异均无统计学意义(P>0.05)。结论:外科手术取精时间对卵胞浆内单精子注射临床结局无显著影响。Objective: To investigate the effect of surgical sperm extraction timing on the clinical outcomes of intracytoplasmic sperm injection(ICSI). Methods: Totally 839 cases of surgically obtained sperm were analyzed for fresh cycle of ICSI treatment. According to the operation time, they were divided into ICSI group on the day of sperm extraction and ICSI group on the next day. The fertilization rate, cleavage rate, high quality embryo rate, implantation rate, clinical pregnancy rate, abortion rate and other results were compared between the two ICSI groups. Results: Embryo culture in vitro and clinical results showed that there was no significant difference in fertilization rate, maturation rate, cleavage rate, D3 quality embryo rate, implantation rate, clinical pregnancy rate and abortion rate between ICSI group on the day of surgical sperm extraction and ICSI group on the next day(P>0.05). Conclusion: The surgical sperm extraction time has no significant effect on the clinical outcomes of intracytoplasmic sperm injection.

关 键 词：无精子症 手术取精 卵胞浆内单精子注射 取精时间 

分 类 号：R714.8[医药卫生—妇产科学]