水杨酸麻黄碱对小鼠脑皮层电图活动及其功率谱的影响  

Effect of Ephedrine salicylate on central nervous system by lectrocorticogram in mice

作　　者：王锐[1] 闫琳[2] 陆钊罡[3] 彭晓东[1] 曹秀琴[1] 李娟[1] 林枫[4] 石凯 WANG Rui;YAN Lin;LU Zhaogang;PENG Xiaodong;CAO Xiuqin;LI Juan;LIN Feng;SHI Kan(Department of Pharmacology,Ningxia Medical University,Yinchuan 750004,China;Functional Experimental Teaching Center of Basic Medical Science,Ningxia Medical University,Yinchuan 750004,China;Department of Pharmacy,Ningxia Hui Aotonomous Region People's Hospital,Yinchuan 750002,China;School of Chemistry and Chemical Engineering,Ningxia University,Yinchuan 750021,China;Department of Obstetrics and Gynecology,Yinchuan Maternal and Child Health Hospital,Yinchuan 750001,China)

机构地区：[1]宁夏医科大学药理学系,宁夏银川750004 [2]宁夏医科大学基础医学实验教学示范中心机能实验中心,宁夏银川750004 [3]宁夏回族自治区人民医院药学部,宁夏银川750002 [4]宁夏大学化学化工学院,宁夏银川750021 [5]宁夏银川市妇幼保健院产科,宁夏银川750001

出　　处：《宁夏医学杂志》2020年第2期104-107,共4页Ningxia Medical Journal

基　　金：国家自然科学基金项目(818600640);宁夏重点研发计划项目(2016KJHM108)。

摘　　要：目的探讨水杨酸麻黄碱对小鼠皮层脑电活动的影响。方法将40只小鼠随机分为4组,分别在腹腔注射水杨酸麻黄碱25、50、100 mg/kg和生理盐水,采用电生理学方法测定小鼠脑皮层电图总功率、δ主波频率及频率分配,分析水杨酸麻黄碱对其变化的影响。结果水杨酸麻黄碱在25、50、100 mg/kg剂量组对脑电总功率未见有明显影响。水杨酸麻黄碱100 mg/kg剂量组在给药后15 min时,δ+θ频段之和占总功率的比例升高(P<0.05),α+β频段之和占总功率的比例降低(P<0.05)。水杨酸麻黄碱50 mg/kg剂量组在给药后15~30 min时,δ+θ频段之和占总功率的比例升高(P<0.05),α+β频段之和占总功率的比例降低(P<0.05)。50、100 mg/kg剂量组小鼠脑皮层电图主波频率在15、120 min升高(P<0.05)。水杨酸麻黄碱25 mg/kg可使小鼠脑皮层电图主波频率升高(P<0.05),在给药后120 min时δ+θ频段之和占总功率的比例降低(P<0.05),α+β频段之和占总功率的比例升高(P<0.05)。结论与麻黄碱相比,水杨酸麻黄碱对中枢神经的兴奋性降低。Objective To investigate the effects of Ephedrine Salicylate on Electrocorticogram(ECoG) in mice.Methods Fouty mice were randomly divided into four group. They were intraperitoneally injected with 25,50,100 mg/kg of ephedrine salicylate and normal saline respectively. The total power,document frequency and frequency distribution were measured by the ECoG.Result The total power was not changed in Ephedrine Salicylate(25,50,100 mg/kg) treated group. Compared with normal saline group,the sum of α wave and β wave in the Ephedrine Salicylate(50 and 100 mg/kg) treated group were significantly decreased(P<0.05),meanwhile the sum of δ wave and θ wave was increased(P<0.05). The main wave frequency of electrocorticogram of mice in 50 mg/kg and 100 mg/kg dose groups increased in 15 min and 120 min(P<0.05). Ephedrine salicylate(25 mg/kg) increased the frequency of main wave of ECoG in mice(P<0.05). The proportion of δ + θ frequency band in total power decreased(P<0.05),and the proportion of α + β frequency band in total power increased(P<0.05).Conclusion Compared with Ephedrine,excitability of Ephedrine salicylate is decreased on central nervous system.

关 键 词：水杨酸麻黄碱 脑皮层电图 总功率 频率分配 

分 类 号：R285[医药卫生—中药学]