新生儿抗生素相关性腹泻的临床研究  

Clinical study of antibiotic-related diarrhea in neonates

作　　者：陈一静 Chen Yijing(Department of Neonatology,the People's Hospital of Shimen County,Hunan Shimen 415300)

机构地区：[1]石门县人民医院新生儿科,湖南石门415300

出　　处：《中国社区医师》2020年第13期83-83,85,共2页Chinese Community Doctors

摘　　要：目的:探究新生儿应用抗生素的相关性腹泻发病率及发病因素。方法:2017年4月-2018年5月收治新生儿140例,记录抗生素应用情况,根据是否发生腹泻分为正常组与腹泻组各70例。对比抗生素应用引发的相关性腹泻情况,分析发病因素。结果:腹泻组抗生素用药比例明显高于正常组,差异有统计学意义(P<0.05)。腹泻组联合用药13例,广谱抗生素用药18例;正常组均为应用窄谱针对性抗生素。结论:新生儿治疗中应用抗生素,可能会导致新生儿出现抗生素相关性腹泻,在临床应用时需要慎重。而在新生儿应用抗生素时,应尽可能选择窄谱针对性抗生素,减少广谱抗生素和联合用药方案,这样能够有助于避免对新生儿的正常肠道造成影响而引发腹泻。Objective:To explore the incidence and pathogenesis of antibiotic-related diarrhea in neonates.Methods:From April 2017 to May 2018,140 neonates were enrolled and antibiotic use was recorded,they were divided into the normal group and the diarrhea group according to whether diarrhea occurred.The related diarrhea caused by antibiotic use was compared and the pathogenesis factors were analyzed.Results:The proportion of antibiotics in diarrhea group was higher than normal group,the difference was statistically significant(P<0.05).13 patients in the diarrhea group were treated with combination drugs and 18 patients were treated with broad spectrum antibiotics;The normal group used narrow spectrum targeted antibiotics.Conclusion:The application of antibiotics in the treatment of neonates is more likely to lead to antibiotic related diarrhea in neonates,it needs to be careful in clinical application.When applying antibiotics in neonates,narrow spectrum targeted antibiotics should be chosen as far as possible to reduce broad spectrum antibiotics and combination regimens,which can help to avoid causing diarrhea for the normal intestinal tract of neonates.

关 键 词：叶酸 锌制剂 小儿腹泻病 治疗方案 

分 类 号：R722.1[医药卫生—儿科]