平之胶囊联合西医常规疗法治疗急性缺血性中风病风痰瘀阻证临床研究  

Clinical Study on Pingzhi Capsules Combined with Conventional Western Medicine Therapy for Treatment of Acute Ischemic Stroke with Anemogenous Phlegm and Stagnant Blood Obstruct Type

作　　者：翟宏伟[1] 尹梅 邹慧娟 ZHAI Hongwei;YIN Mei;ZOU Huijuan(The Second Traditional Chinese Hospital of Taian City,Taian 271000,China)

机构地区：[1]泰安市中医二院,山东泰安271000

出　　处：《中国中医药信息杂志》2020年第5期18-22,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：泰安市科技发展计划(201440774)。

摘　　要：目的观察平之胶囊联合西医常规疗法治疗急性缺血性中风病风痰瘀阻证临床疗效。方法采用随机数字表法将200例缺血性中风病风痰瘀阻证患者分为治疗组和对照组各100例。2组均予西医常规疗法,治疗组并予平之胶囊,每日3粒,每日3次,口服。2组均连续治疗2个月。观察2组临床疗效,比较2组治疗前后中医症状积分、美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力量表(ADL)评分,血脂、超敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)、同型半胱氨酸(Hcy)、血液流变学指标,观察2组不良反应。结果治疗组、对照组分别脱落1、2例。治疗组总有效率为88.9%(88/99),对照组为69.4%(68/98),2组比较差异有统计学意义(P<0.05)。与本组治疗前比较,2组治疗后中医症状积分、NIHSS评分明显下降,ADL评分明显升高(P<0.05);2组治疗后比较,治疗组上述评分明显优于对照组(P<0.05)。与本组治疗前比较,治疗组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平明显降低(P<0.05),对照组TC水平明显降低(P<0.05);2组治疗后比较,治疗组TC、LDL-C水平明显低于对照组(P<0.05)。与本组治疗前比较,2组治疗后MMP-9、hs-CRP、Hcy水平明显降低(P<0.05);2组治疗后比较,治疗组MMP-9、hs-CRP、Hcy水平明显低于对照组(P<0.05,P<0.01)。与本组治疗前比较,治疗组血浆黏度、纤维蛋白原(FIB)、全血黏度(高切、低切)、红细胞聚集指数明显下降(P<0.05,P<0.01),对照组FIB、红细胞聚集指数明显下降(P<0.05);2组治疗后比较,治疗组FIB、全血黏度低切、红细胞聚集指数明显低于对照组(P<0.05)。2组均未见明显不良反应。结论平之胶囊联合西医常规疗法治疗急性缺血性中风病风痰瘀阻证疗效显著,可改善患者中医症状,降低血脂,保护血管内皮细胞,延缓病情进展。Objective To observe the clinical efficacy of Pingzhi Capsules combined with conventional Western medicine therapy for patients with acute ischemic stroke of anemogenous phlegm and stagnant blood obstruct type. Methods Totally 200 cases of acute ischemic stroke with anemogenous phlegm and stagnant blood obstruct type were randomly divided into the treatment group and the control group, with 100 cases in each group. Both groups were given conventional Western medicine treatment. The treatment group was added with Pingzhi Capsules on the basis of control group, three capsules per day, three times a day, orally. The treatment for both groups lasted for two months. The clinical efficacy of both groups was observed. TCM symptom scores, NIH stroke scale(NIHSS) score, ability of daily life scale(ADL) score, blood lipid, high-sensitivity C-reactive protein(hs-CRP), and matrix metalloproteinase-9(MMP-9), homocysteine(Hcy), hemorheology indicators of both groups before and after treatment were compared. The adverse reactions in the two groups were observed. Results The treatment group and the control group lost 1 and 2 cases, respectively. The total effective rate was 88.9%(88/99) in the treatment group and 69.4%(68/98) in the control group, with statistical significance(P<0.05). Compared with before treatment, the TCM symptom scores and NIHSS score were significantly reduced, and the ADL score significantly increased in the two groups after treatment(P<0.05);After treatment, the above scores in the treatment group was significantly better than that in the control group(P<0.05). Compared with before treatment, the total cholesterol(TC), triacylglycerol(TG), and low density lipoprotein cholesterol(LDL-C) in the treatment group were significantly reduced(P<0.05), and the TC level in the control group was significantly reduced(P<0.05);After treatment, the levels of TC and LDL-C in the treatment group were significantly lower than those in the control group(P<0.05). Compared with before treatment, the levels of MMP-9, hs-CRP a

关 键 词：缺血性中风病 平之胶囊 风痰瘀阻证 临床疗效 

分 类 号：R277.733[医药卫生—中医学]