去甲肾上腺素、苯肾上腺素、麻黄碱治疗子痫前期产妇剖宫产术中低血压的效果观察  

Therapeutic efficacy of norepinephrine, phenylephrine versus ephedrine in preeclampsia puerperae with hypotension during cesarean section

作　　者：卢钊楷 缪丽琳 莫桂熙 郑穗瑾 王彩红 陈醒霞 张小利 LU Zhao-kai;MIAO Li-lin;MO Gui-xi;ZHENG Sui-jin;WANG Cai-hong;CHEN Xing-xia;ZHANG Xiao-li(Department of Anesthesiology,Guangdong Medical University,Dongguan 523945,China;Department of Obstetrics and Gynecology,Affiliated Houjie Hospital,Guangdong Medical University,Dongguan 523945,China;Department of Anesthesiology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China)

机构地区：[1]广东医科大学附属东莞厚街医院麻醉科,广东东莞523945 [2]广东医科大学附属东莞厚街医院妇产科,广东东莞523945 [3]广东医科大学附属医院麻醉科,广东湛江524000

出　　处：《广东医科大学学报》2020年第2期234-237,共4页Journal of Guangdong Medical University

基　　金：东莞市社会科技发展一般项目(No.201950715023465)。

摘　　要：目的比较去甲肾上腺素、苯肾上腺素、麻黄碱对子痫前期产妇在腰麻下剖宫产期间低血压的疗效。方法 180例腰麻下剖宫产术中低血压的先兆子痫产妇随机分成N、P、E组,分别使用去甲肾上腺素、苯肾上腺素、麻黄碱治疗。比较3组生命体征、脐动脉血气分析、不良反应和新生儿预后。结果 E组标准化心率最高,P组最低(P<0.05)。N组心动过速发生率较E组低(P<0.05),心动过缓发生率较P组低(P<0.05)。E组恶心呕吐发生率最高(P<0.05)。与E组相比,N组脐动脉碱剩余、HCO3-、乳酸差异均有统计学意义(P<0.05)。结论去甲肾上腺素、苯肾上腺素对子痫前期产妇在腰麻下剖宫产低血压的疗效、安全性较好。Objective To compare the efficacy of norepinephrine, phenylephrine and ephedrine in preeclampsia puerperae with spinal anesthesia-induced hypotension during cesarean section. Methods A total of 180 preeclampsia puerperae with spinal anesthesia-induced hypotension were randomly treated with norepinephrine(N group), phenylephrine(P group) and ephedrine(E group). Vital signs, arterial blood gas, adverse reactions, and neonatal outcomes were compared among three groups. Results Standardized heart beats were the highest in E group and lowest in P group(P<0.05). Tachycardia and bradycardia in N group was fewer than in E and P groups(P<0.05), respectively. The incidence of nausea and vomiting topped in E group(P<0.05). There were significant differences in levels of base excess, HCO3- and lactic acid between N and E groups(P<0.05). Conclusion Norepinephrine and phenylephrine are effective and safe for preeclampsia puerperae with spinal anesthesia-induced hypotension.

关 键 词：先兆子痫 去甲肾上腺素 苯肾上腺素 麻黄素 

分 类 号：R614.41[医药卫生—麻醉学]