青岛成年居民血清肝酶与新诊断2型糖尿病关联研究  

The association of serum liver enzyme and newly diagnosed type 2 diabetes mellitus in adults of Qingdao city

作　　者：苑东敏 崔静 任杰[3] 辛化雷 杨帆[4] 王云云 孙健平 YUAN Dong-min;CUI Jing;REN Jie;XIN Hua-lei;YANG Fan;WANG Yun-yun;SUN Jian-ping(School of Public Health and Management,Weifang Medical University,Weifang,Shandong Province 261053,China)

机构地区：[1]潍坊医学院公共卫生与管理学院,山东省潍坊261053 [2]青岛市疾病预防控制中心青岛市预防医学研究院 [3]山东省疾病预防控制中心慢性非传染性疾病防制所 [4]青岛大学公共卫生学院

出　　处：《中国慢性病预防与控制》2020年第3期187-190,194,共5页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：青岛糖尿病预防项目(WDF05-108 WDF07-308);青岛市科技局立项项目(19-6-1-5-nsh);青岛市医疗卫生优秀人才培养项目。

摘　　要：目的探讨丙氨酸氨基转移酶(ALT)和γ-谷氨酰基转移酶(GGT)水平与新诊断2型糖尿病(T2DM)患病之间的关联,为T2DM的防治提供科学依据。方法于2006年1月和2009年1月采用4阶段分层随机抽样的方法,共选取青岛地区7819名35~74岁成年居民作为调查对象,进行问卷调查、体格检查和实验室检测。采用SPSS 23.0软件进行t检验、χ^2检验,ALT、GGT水平与空腹血糖(FPG)、餐后2 h血糖(2 h PG)的相关性采用Pearson相关分析,新诊断T2DM患病的影响因素采用多因素非条件logistic回归分析。结果男性新诊断T2DM患病率(13.10%)高于女性(10.70%),女性ALT、GGT水平低于男性,差异均有统计学意义(P<0.01)。Pearson相关分析结果显示,ALT、GGT水平均与FPG(r值分别为0.077、0.115)、2 h PG(r值分别为0.078、0.111)呈正相关,均有统计学意义(P<0.01)。多因素logistic回归分析结果显示,调整混杂因素后,总人群ALT异常(OR=2.48,95%CI:1.75~3.52)、GGT异常(OR=2.83,95%CI:2.24~3.59)均与新诊断T2DM高患病风险相关(P<0.01);男性、女性ALT异常(男性OR=2.68,95%CI:1.57~4.59;女性OR=2.32,95%CI:1.46~3.69)、GGT异常(男性OR=2.48,95%CI:1.84~3.35;女性OR=3.35,95%CI:2.27~4.95)均与新诊断T2DM高患病风险相关(P<0.01)。结论ALT、GGT异常与T2DM高患病风险相关,后续还需要长期研究或干预试验进一步验证。Objective To explore the association of alanine aminotransferase(ALT),γ-glutamyltransferase(GGT)levels with the risk of newly diagnosed type 2 diabetes mellitus(T2DM),and to provide the basis for preventing and treating the T2DM.Methods From January of 2006 to January of 2009,a four-stage stratified random sampling method was used to select 7819 adults(35-74 years old)in Qingdao city as the subjects.The investigation was performed by questionnaire,physical examination and laboratory test.The t test andχ^2 test were used to analyze the data,the Pearson correlation was used to analyze the correlation between ALT or GGT levels and fasting plasma glucose(FPG)or 2 h post-load plasma glucose(2 h PG).Multivariate unconditional logistic regression was used to analyze the influencing factors of T2DM.The used software was SPSS 23.0.Results The morbidity of newly diagnosed T2DM in males was 13.10%which was significantly higher than that in females(10.70%),the levels of ALT and GGT in females were significantly lower than those in males,P<0.01.Pearson correlation illustrated that ALT and GGT levels were positively correlated with FPG(ALT:r=0.077,GGT:r=0.115)and 2 h PG(ALT:r=0.078,GGT:r=0.111),P<0.01.Multivariable logistic regression revealed that after adjusting confounding factors,abnormal ALT(OR=2.48,95%CI:1.75-3.52)and abnormal GGT(OR=2.83,95%CI:2.24-3.59)were related to high risk of newly diagnosed T2DM(P<0.01);abnormal ALT was related to high risk of newly diagnosed T2DM in males(OR=2.68,95%CI:1.57-4.59)and in females(OR=2.32,95%CI:1.46-3.69);and abnormal GGT was related to high risk of newly diagnosed T2DM in males(OR=2.48,95%CI:1.84-3.35)and in females(OR=3.35,95%CI:2.27-4.95),P<0.01.Conclusion The abnormal ALT and GGT were related to higher risk of T2DM.In further,longterm studies or intervention trials should be needed.

关 键 词：丙氨酸氨基转移酶 Γ-谷氨酰基转移酶 糖尿病 2型 

分 类 号：R587.1[医药卫生—内分泌]