PRDM蛋白家族在神经系统中的作用  

Role of the PRDM Protein Family in the Nervous System

作　　者：王存金 潘昱辰[2] 陈莹 庄英涵 Thomas Behnisch WANG Cun-Jin;PAN Yu-Chen;CHEN Ying;ZHUANG Ying-Han;Thomas Behnisch(The Institutes of Brain Science,the State Key Laboratory of Medical Neurobiology,and the Collaborative Innovation Center for Brain Science,Fudan University,Shanghai 200032,China;Department of Internal medicineⅢ,Jiangsu Provincial Corps Hospital,Chinese People's Armed Police Force,Yangzhou 225003,China)

机构地区：[1]复旦大学脑科学研究院,医学神经生物学国家重点实验室,脑科学协同创新中心,上海200032 [2]武警江苏总队医院内三科,扬州225003

出　　处：《生理科学进展》2020年第2期87-93,共7页Progress in Physiological Sciences

基　　金：国家自然科学基金(81500947,31871076)资助课题。

摘　　要：PRDM(PRDI-BF1 and RIZ homology domain containing)蛋白家族是一类包含PR结构域和若干个锌指结构的转录调控蛋白,具有众多家庭成员,广泛表达于灵长类、两栖类和啮齿类等动物中。以往研究发现,PRDM蛋白家族(PRDMs)在细胞增殖、分化、成熟过程中,以及机体造血、生殖和肿瘤发生等生理和病理过程中发挥重要的调控作用。近年来随着研究的不断深入,有关PRDMs在神经系统中所发挥的作用也逐渐引起科学界的广泛关注。目前的研究证实了PRDMs在神经系统发育、中枢神经系统炎症以及神经干细胞增殖和分化等过程中扮演着重要的角色。本文就PRDMs在神经系统中的作用作一综述。PRDM protein family is a transcriptional regulatory protein containing PR domain and several zinc finger structures. It has many family members and is widely expressed in primates,amphibians and rodents. Previous studies have found that PRDMs play important regulatory roles in many physiological and pathological processes such as cell proliferation,differentiation and maturation,as well as hematopoiesis,reproduction,metabolism,and tumorigenesis. In recent years,the roles of PRDMs in the nervous system have gradually attracted extensive attention from the scientific community. It has been confirmed that PRDMs play many roles in the development of the nervous system,central nervous system inflammation and the proliferation and differentiation of neural stem cells. In this review,we summarize recent studies on the roles of PRDMs in the nervous system.

关 键 词：PRDM 神经系统 表观遗传 信号通路 

分 类 号：R34[医药卫生—基础医学] R338