2008-2017年佛山市无偿献血人群梅毒流行趋势分析  

Trend of Syphilis Infection among Voluntary Blood Donors in Foshan City from 2008 to 2017

作　　者：林俊填[1] 伍伟健[1] 杨富燕 余玉婷[1] 黎艳华[1] 余晋林[1] LIN Jun-Tian;WU Wei-Jian;YANG Fu-Yan;YU Yu-Ting;LI Yan-Hua;YU Jin-Lin(Foshan Central Blood Station,Foshan 528000,Guangdong Province,China;Department of Obstetrics Nanhai District People's Hospital,Foshan 528200,Guangdong Province,China)

机构地区：[1]佛山市中心血站,广东佛山528000 [2]佛山市南海区人民医院产科,广东佛山528200

出　　处：《中国实验血液学杂志》2020年第2期641-645,共5页Journal of Experimental Hematology

摘　　要：目的:了解佛山市无偿献血人群的梅毒感染流行情况,为完善输血安全措施提供参考依据。方法:选取2008-2017年佛山市无偿献血者657 382例,对其血液标本进行梅毒螺旋体(treponema pallidum,TP)抗体检测,并对TP抗体阳性的检出情况及流行病学资料进行统计学分析。采用ELISA法对梅毒抗体筛查检测,对初检结果阳性者进一步采用梅毒螺旋体血凝试验(TPHA)进行确认。结果:2008年1月至2017年12月佛山市无偿献血人群(657 382人)共检测出梅毒螺旋体抗体阳性者2 502例,总阳性率为0.38%,2008-2017年的梅毒螺旋体抗体阳性率分别为0.43%、0.40%、0.41%、0.43%、0.50%、0.32%、0.36%、0.32%、0.37%和0.32%,抗体阳性率呈逐渐下降的态势(P <O.05)。657 382份无偿献血者标本中,梅毒螺旋体抗体筛查呈阳性为2 502份,筛查阳性率为0.38%,其中,2015-2017年梅毒螺旋体抗体筛查呈阳性为791份,确认阳性数为676例,确认阳性率为0.34%,确认阳性符合率为85.46%。2015-2017年676例梅毒螺旋体抗体阳性者中以男性为主(0.35%,577/164 484);平均年龄为32(18-53)岁,其中以35-44岁者为主(0.33%,138/41 858);文化程度以大专以下低学历者为主(0.32%,571/180 917);职业以外来务工、公司职员为主(0.39%,452/115 101);婚姻状况以未婚为主(0.29%,377/130 905);籍贯以非本地籍人士为主(0.29%,570/198 063)。结论:2008-2017年梅毒螺旋体阳性率总体呈下降趋势;2015-2017年确认的梅毒螺旋体抗体阳性者当中以非本地籍、未婚、低学历男性为主,且半数以上是外来务工或公司职员。Objective:To investigate the prevalence of syphilis infection in voluntary blood donors in Foshan City,so as to provide reference for improving the infusion blood safety strategy of city.Methods:A total of 657382 voluntary blood donors in Foshan City from January 2008 to December 2017 were selected.The blood samples were tested for treponema pallidum.The prevalence trends,the detection rate of treponema pallidum infection and epidemiological data were statistically analyzed.Enzyme-linked immunosorbent assay(ELISA)was performed for antibody screening in blood samples.The two-hole retest was then performed for the samples which were positive in initial test,meanwhile,they were also confirmed by the treponema hemagglutination blood coagulation test(TPHA).Results:First,the annual infection rate of treponema pallidum in Foshan City from January 2008 to December 2017 was 0.43%,0.40%,0.41%,0.43%,0.50%,0.32%,0.36%,0.32%,0.37%and 0.32%,respectively.A total of 2502 cases of treponema pallidum infection were detected,the overall infection rate was 0.38%,and the infection rate decreased year by year(x2=23.826,P<0.05).Second,among the 657382 samples of voluntary blood donors,2502 were showed the positive treponema pallidum antibody(0.38%).In 2015-2017,791 donors were showed positive treponema pallidum antibody,676 case out of which were confirmed positive,0.34%with the positive coincidence rate of 85.46%.Third,this group of 676 syphilis infection cases were male-dominated(0.35%,577/164484).The age distribution was 18-53 years old,and the average age was 32 years,among which 35-44 years old accounted for 0.33%(138/41858).The education level of in donors with treponema pallidom positive mainly ranked at low or lower levels under janior college(0.32%,571/180917).The occupation is mainly outside work and company staff(0.39%,452/115101).The marital status is mainly unmarried(0.29%,377/130905).The place of origin is mainly non-local(0.29%,570/198063).Conclusion:The positive rate of treponema pallidum shows a downward trend in 2008-

关 键 词：献血者 梅毒螺旋体 感染 流行趋势 输血安全 

分 类 号：R759.1[医药卫生—皮肤病学与性病学] R457.1[医药卫生—临床医学]