小剂量阿司匹林联合来曲唑对多囊卵巢综合征患者血清内脂素、单核细胞趋化蛋白1及妊娠率的影响  

Effects of low-dose aspirin combined with letrozole on serum visfatin,monocyte chemoattractant protein-1 and pregnancy rate in patients with polycystic ovary syndrome

作　　者：王晓禾[1] 马骐[1] 钱正宇[1] 潘晓艳 Wang Xiaohe;Ma Qi;Qian Zhengyu;Pan Xiaoyan(Department of Reproduction,the Third People's Hospital of Datong,Datong,Shanxi 037000,China;Department of Clinical Laboratory,the Third People's Hospital of Datong,Datong,Shanxi 037000,China)

机构地区：[1]大同市第三人民医院生殖科,山西省037000 [2]大同市第三人民医院检验科,山西省037000

出　　处：《中国基层医药》2020年第6期665-669,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的:探讨小剂量阿司匹林联合来曲唑对多囊卵巢综合征患者血清内脂素、单核细胞趋化蛋白1(MCP-1)及妊娠率的影响。方法:选择大同市第三人民医院2016年11月至2018年11月接诊的多囊卵巢综合征患者110例,采用随机数字表法分为观察组60例、对照组50例,对照组给予来曲唑治疗,观察组在对照组基础上联合小剂量阿司匹林治疗,均连续治疗3个月经周期。比较两组治疗前后血清内脂素、MCP-1、性激素、子宫动脉血流及妊娠情况、不良反应。结果:治疗后,观察组血清内脂素、MCP-1、睾酮(T)、促黄体生成素(LH)、促黄体生成素/卵泡刺激素(LH/FSH)、子宫动脉搏动指数(PI)和阻力指数(RI)分别为(11.03±2.17)ng/mL、(99.31±14.50)ng/L、(1.57±0.29)mmol/L、(6.57±1.30)U/L、(1.16±0.22)、(1.07±0.24)、(0.41±0.08),均明显低于对照组的(15.57±2.56)ng/mL、(121.29±20.37)ng/L、(1.78±0.32)mmol/L、(8.40±1.88)U/L、(1.50±0.27)、(1.45±0.29)、(0.57±0.11),差异均有统计学意义( t=10.068、6.593、3.608、6.012、7.278、7.521、8.815,均 P<0.05);观察组排卵率、妊娠率分别为81.67%(49/60)、35.00%(21/60),均高于对照组的64.00%(32/50)、18.00%(9/50)(χ 2=4.385、3.974,均 P<0.05);两组不良反应发生率差异无统计学意义( P>0.05)。 结论:小剂量阿司匹林联合来曲唑促排卵治疗多囊卵巢综合征,可明显降低血清内脂素、MCP-1表达,调节性激素水平,改善子宫动脉血流,提高妊娠率,且不增加药物不良反应。Objective To study the effect of low-dose aspirin combined with letrozole on serum visfatin,monocyte chemoattractant protein-1(MCP-1)and pregnancy rate in patients with polycystic ovary syndrome(PCOS).Methods From November 2016 to November 2018,110 patients with PCOS in the Third People's Hospital of Datong were selected.According to the random number table,they were divided into the observation group(60 cases)and the control group(50 cases).The control group was treated with letrozole,while the observation group was given letrozole combined with low-dose aspirin.The patients were continuously treated for 3 menstrual cycles.The changes of the serum visfatin,MCP-1,sex hormones,uterine artery blood flow before and after treatment,pregnancy and adverse reactions were compared between the two groups.Results After treatment,the serum visfatin,MCP-1,testosterone(T),luteinizing hormone(LH),LH/follicular estrogen(FSH),uterine arterial pulsation index(PI)and resistance index(RI)in the observation group were(11.03±2.17)ng/mL,(99.31±14.50)ng/L,(1.57±0.29)mmol/L,(6.57±1.30)U/L,(1.16±0.22),(1.07±0.24),(0.41±0.08),respectively,which were significantly lower than those in the control group[(15.57±2.56)ng/mL,(121.29±20.37)ng/L,(1.78±0.32)mmol/L,(8.40±1.88)U/L,(1.50±0.27),(1.45±0.29),(0.57±0.11)],the differences were statistically significant(t=10.068,6.593,3.608,6.012,7.278,7.521,8.815,all P<0.05).The ovulation rate and pregnancy rate in the observation group were 81.67%(49/60)and 35.00%(21/60),respectively,which were significantly higher than those in the control group[64.00%(32/50),18.00%(9/50)](χ^2=4.385,3.974,all P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Low-dose aspirin combined with letrozole in the treatment of PCOS can effectively reduce the serum visfatin and MCP-1,regulate the sex hormones levels,improve uterine artery blood flow,improve pregnancy rate,and without increasing adverse drug reactions,so it'

关 键 词：多囊卵巢综合征 阿司匹林 来曲唑 药物疗法 联合 内脂素 单核细胞化学吸引蛋白质类 性腺激素类 子宫动脉 妊娠 

分 类 号：R711[医药卫生—妇产科学]