健康志愿者清醒时疼痛程度与镇痛伤害感受指数相关性研究  

Study on the correlation between pain level and analgesia nociception index in conscious healthy volunteers

作　　者：闫琦[1] 安海燕[1] 冯艺[1] YAN Qi;AN Hai-Yan;FENG Yi(Department of Anesthesiology and Pain Medicine,Peking university people's Hospital,Beijing 100044,China)

机构地区：[1]北京大学人民医院麻醉和疼痛医学科,北京100044

出　　处：《中国疼痛医学杂志》2020年第3期185-190,共6页Chinese Journal of Pain Medicine

基　　金：宜昌人福药业有限责任公司资助(2018-Z-17)

摘　　要：目的:本研究目的在于探讨镇痛伤害感受指数(analgesia nociception index,ANI)是否可用于清醒受试者急性疼痛的客观评价,研究ANI与视觉模拟评分法(visual analogue scale,VAS)的相关性。方法:本试验为预实验,受试者共40人,采用随机双盲交叉对照试验,用冷痛模型对受试者右前臂尺侧皮肤进行冷痛刺激,记录疼痛时ANI与VAS数值。采用SPSS 13.0统计学软件进行统计学分析,计量资料以均数±标准差(x±SD)表示,组间比较采用t检验。ANI与VAS间进行Pearson相关分析。结果:在健康受试者中ANI与VAS存在一定程度的负相关,相关系数为-0.267。结论:尽管ANI与VAS存在一定的负相关,但目前ANI并不能取代VAS准确评估疼痛程度。Objective:To explore the correlation between analgesia nociception index(ANI)and visual analogue scale(VAS)in conscious healthy volunteers and the possibility of using ANI for objectively assessing acute pain.Methods:Forty healthy volunteers were enrolled in this randomized,double-blind,cross-over trial.The cold pressor model was used to stimulate the volunteers in the forearm skin,and record their ANI and VAS data immediately when the pain stimulation was over.SPSS 13.0 statistical software was used for statistical analysis.The data was expressed as mean±standard deviation(x±SD).The t-test was used for comparison between groups.Pearson correlation analysis was conducted for ANI and VAS.Results:There is a small but statistically significant negative correlation between ANI and VAS.The correlation efficient is-0.267.Conclusion:ANI cannot replace VAS to accurately assess pain intensity despite the negative correlation between ANI and VAS.

关 键 词：疼痛评估 镇痛伤害感受指数 视觉模拟评分法 清醒受试者 

分 类 号：R402[医药卫生—临床医学]