左旋咪唑治疗白癜风的效果评价及对患者T淋巴细胞亚群和Th1/Th2类细胞因子的影响  

Effect of Levamisole in Vitiligo and the T Lymphocyte Subsets and Th1/Th2 Cytokines in patients

作　　者：郄永强[1] 周会杰[1] 张恒坡[2] QIE Yong-qiang;ZHOU Hui-jie;ZHANG Heng-po(Department of Nuclear Medicine,Puyang Anyang District Hospital,Anyang 455000,China;Department of Dermatology,Puyang Anyang District Hospital,Anyang 455000,China)

机构地区：[1]濮阳市安阳地区医院核医学科,安阳455000 [2]濮阳市安阳地区医院皮肤科,安阳455000

出　　处：《中国合理用药探索》2020年第4期74-77,共4页Chinese Journal of Rational Drug Use

摘　　要：目的:观察左旋咪唑对白癜风的治疗效果,并探讨其对患者T淋巴细胞亚群和Th1/Th2类细胞因子的影响。方法:84例白癜风患者按随机数字表分为两组:对照组给予常规治疗,观察组在此基础上给予左旋咪唑治疗。观察患者的临床疗效,比较治疗前后T淋巴细胞亚群及Th1/Th2类细胞因子水平变化,并记录不良反应发生情况。结果:观察组治疗总有效率为97.62%,高于对照组的83.33%(P<0.05);T淋巴细胞亚群及Th1/Th2类细胞因子检测结果显示,治疗后CD3+、CD4+、CD4+/CD8+、IL-4均高于治疗前,其中观察组分别为(63.15±6.22)%、(42.46±3.25)%、(2.00±0.27)和(61.30±6.62)pg/ml,对照组分别为(59.86±6.07)%、(37.20±3.04)%、(1.61±0.20)和(55.84±6.19)pg/ml,观察组中各指标均高于对照组(P<0.05);治疗后CD8+、IFN-γ均低于治疗前(P<0.05),观察组分别为(21.28±2.07)%和(47.20±4.51)pg/ml,对照组分别为(23.11±2.05)%和(55.19±5.34)pg/ml,观察组中各指标均低于对照组,差异均有统计学意义(P<0.05);观察组总不良反应发生率略高于对照组。结论:左旋咪唑可增强白癜风患者临床疗效,且安全性良好,其可能机制是通过调节T淋巴细胞亚群水平以及促进Th1/Th2类细胞因子恢复来达到治疗作用。Objective:To observe the effect of levamisole on vitiligo patients,and to explore its effect on T lymphocyte subsets and Th1/Th2 cytokines.Methods:84 patients with vitiligo were divided into 2 groups.The control group was given routine treatment,and the experimental group was additionally given levamisole on this basis.The treatment efficacy,changes of T lymphocyte subsets and Th1/Th2 cytokines,as well as adverse reactions after treatment were compared between groups.Results:The total effective rate of the experimental group was 97.62%,which was higher than that of 83.33%in the control group(P<0.05).After treatment,the results of CD3+,CD4+,CD4+/CD8+and IL-4 in the experimental group were(63.15±6.22)%,(42.46±3.25)%,(2.00±0.27)and(61.30±6.62)pg/ml,significantly higher than those results in control groups of(59.86±6.07)%,(37.20±3.04)%,(1.61±0.20)and(55.84±6.19)pg/ml respectively(P<0.05).The CD8+and IFN-γ obviously decreased after treatment in both groups(P<0.05),with(21.28±2.07)%and(47.20±4.51)pg/ml in the experiment group and(23.11±2.05)%and(55.19±5.34)pg/ml in the control group(P<0.05).The total incidence of adverse reactions in the experimental group was slight higher than those in the control group.Conclusion:Levamidazole shows efficacy and safety on patients with vitiligo.The mechanisms may be related to the regulation effects of levamidazole on the level of T lymphocyte subsets and the recovery of Th1/Th2 cytokines.

关 键 词：左旋咪唑 白癜风 T淋巴细胞亚群水平 TH1/TH2类细胞因子 

分 类 号：R758.4[医药卫生—皮肤病学与性病学]