类风湿关节炎相关间质性肺疾病患者血生化指标水平及CT影像特点分析  

Levels of Blood Biochemical Indices and CT Image Features in Patients with Rheumatoid Arthritis Associated Interstitial Lung Disease

作　　者：冯要菊[1] FENG Yao-ju(Department of Nephropathy and Rheumatology,Nanyang Medical College,Nanyang 473000,Henan Province,China)

机构地区：[1]南阳医学高等专科学校第一附属医院肾病风湿科,河南南阳473000

出　　处：《中国CT和MRI杂志》2020年第2期41-43,87,共4页Chinese Journal of CT and MRI

摘　　要：目的探究类风湿关节炎相关间质性肺疾病(RA-ILD)患者血生化指标水平及CT影像特点。方法回顾性分析2017年2月至2018年2月于我院就诊并确诊为RA-ILD180例患者(观察组)的临床资料,分析患者CT影像特点。选取同期类风湿关节炎(RA)患者30例作为对照,对比两组患者的血生化指标水平。结果观察组患者血清KL-6、RF及ACCP水平均高于对照组,且差异具有统计学意义(P<0.05)。CT影像病变部位显示:所有患者均为双肺同时受累,左、右下肺均受累;病变类型显示:大部分患者的CT影像显示为网格影(43.89%)或渗出斑片浸润/实变影(13.89%);变病范围显示:有65例(36.11%)患者累及2个肺叶,82例(45.56%)患者累及3个肺叶,33例(18.33%)患者累及5个肺叶。结论RA-ILD患者CT影像主要表现为网格影或渗出斑片浸润/实变影,RA-ILD患者易双肺同时受累,RA-ILD患者血清KL-6、RF及ACCP水平较RA患者明显升高,提示RA-ILD可能与血清KL-6、RF及ACCP水平密切相关。Objective To investigate the levels of blood biochemical indexes and CT image features in patients with rheumatoid arthritis associated interstitial lung disease(RA-ILD). Methods The clinical data of 180 patients with RA-ILD(observation group) who were diagnosed and treated in the hospital during the period from February 2017 to February 2018 were retrospectively analyzed. The CT image features were analyzed. Thirty patients with rheumatoid arthritis(RA) treated in the same period were selected as controls and levels of blood biochemical indexes were compared between the two groups. Results The levels of serum KL-6, RF and ACCP in the observation group were higher than those in the control group(P<0.05). CT images of lesions showed that all patients had both lungs involved, and the left and right lower lungs were involved. The types of lesions showed that CT images of most patients showed grid shadow(43.89%) or exudation patch infiltration/consolidation shadow(13.89%). The range of consolidation showed that 2 lobes in 65 cases(36.11%), 3 lobes in 82 cases(45.56%) and 5 lobes in 33 cases(18.33%) were involved. Conclusion The CT images of patients with RA-ILD mainly include grid shadow or exudation patch infiltration/consolidation shadow. Patients with RAILD easily have simultaneous involvement of both lungs. The levels of serum KL-6, RF and ACCP are higher in patients with RA-ILD than in patients with RA, suggesting that RA-ILD may be closely related to levels of serum KL-6, RF and ACCP.

关 键 词：类风湿关节炎 间质性肺病 血清KL-6 类风湿因子 抗环瓜酸抗体 CT 

分 类 号：R445.3[医药卫生—影像医学与核医学] R593.2[医药卫生—诊断学]