红花冲泡茶对抑郁大鼠模型的安全性和有效性验证  

Pharmacodynamics Experiment of Safflower Brewing Tea Against Depression

作　　者：李亚慧 赵阳[2] 杨斌[2] 高蕊[2] LI Ya-hui;ZHAO Yang;YANG Bin;GAO Rui(Graduate School of the Chinese Academy of Traditional Chinese Medicine,Beijing 100700,China;Xiyuan Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100091,China)

机构地区：[1]中国中医科学院研究生院,北京100700 [2]中国中医科学院西苑医院,北京100091

出　　处：《中医药导报》2020年第5期45-48,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家科技重大专项项目(2017ZX09304003);中医药国际合作专项(GZYYGJ2017010)。

摘　　要：目的:验证红花冲泡茶的安全性及有效性。方法:安全性考察:将大鼠随机分为冲泡茶组和对照组,两组大鼠分别灌胃冲泡茶和饮用水42 d,比较两组大鼠的血常规、肝肾功能、血脂、血糖、重要脏器的脏器指数及肝脏病理切片情况。有效性考察:建立慢性利血平注射导致的抑郁大鼠模型,冲泡茶组和氟西汀组大鼠分别灌胃红花冲泡茶和氟西汀溶液,空白组和模型组大鼠灌胃饮用水,比较4组大鼠行为学测试结果和大脑病理切片。结果:冲泡茶连续服用42 d对大鼠的血常规、肝肾功能、血糖、血脂、重要脏器指数及肝脏均无明显影响;冲泡茶组大鼠在行为学测试中的水平运动、垂直运动及总路程方面均明显高于模型组(P<0.01或P<0.05),并且冲泡茶在一定程度上改善了大鼠大脑海马的结构和排列并增加了细胞数。结论:红花冲泡茶长期口服安全无毒副作用,并有一定的对抗阈下抑郁的作用。Objective:To verify the safety and effectiveness of safflower brewing tea.Methods:(1)Safety inspection:The rats were randomly divided into two groups:safflower brewing tea group and control group,and them in the two groups were infused with tea and drinking water respectively for 42 days.Then the blood routine,liver and kidney function,blood lipid,blood glucose,organ index of important organs and pathological sections of liver were compared between the two groups.(2)Validity investigation:The depression model of rats caused by chronic reserpine injection was established.The rats in the safflower brewing tea group and the control group were respectively given gastric infusion of tea and fluoxetine solution,and the rats in the blank group and the model group were given gastric drinking water.The behavioral test results and brain pathological sections of the four groups were compared.Results:There were no significant effects on blood routine,liver and kidney function,blood glucose,blood lipid,vital organ index and liver in rats after 42 days of safflower brewing tea.The level movement,vertical movement and total distance of the rats in the safflower brewing tea group were significantly higher than those in the model group(P<0.01 or P<0.05).Safflower brewing tea improved the structure and arrangement of the hippocampus and increased the number of cells.Conclusion:Safflower brewing tea is safe and has no side effects for a long time,and has a certain effect on depression under threshold.

关 键 词：阈下抑郁 红花冲泡茶 藏红花 毒性实验 药效学实验 大鼠 

分 类 号：R285.5[医药卫生—中药学]