基于文献计量方法的表观遗传学在中医证候本质研究中的应用分析  

Applied Analysis of Epigenetics based on Bibliometric Method in the Essence Study of TCM Syndromes

作　　者：姜俊杰[1] 刘玉庆[2] 于洋 张华 申浩 魏戌[6] 章轶立 谢雁鸣[1] JIANG Jun-jie;LIU Yu-qing;YU Yang;ZHANG Hua;SHEN Hao;WEI Xu;ZHANG Yi-li;XIE Yan-ming(Institute of Clinical Basic Medicine,Chinese Academy of Traditional Chinese Medicine,Beijing 100700,China;Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine,Beijing 100700,China;Changping District Integrated Traditional Chinese and Western Medicine Hospital,Beijing 100096,China;Administrative Matters Acceptance Service and Complaints Reporting Center of the State Drug Administration,Beijing 100053,China;Fengtai District Changxindian Community Health Service Center,Beijing 100072,China;Wangjing Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100102,China;Beijing University of Traditional Chinese Medicine,Beijing 100029,China)

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]北京中医药大学东直门医院,北京100700 [3]昌平区中西医结合医院,北京100096 [4]国家药品监督管理局行政事项受理服务和投诉举报中心,北京100053 [5]丰台区长辛店社区卫生服务中心,北京100072 [6]中国中医科学院望京医院,北京100102 [7]北京中医药大学,北京100029

出　　处：《中医药导报》2020年第5期83-87,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金青年基金(81603517);中华中医药学会(2017-2019年度)青年人才托举工程项目(CACM-2017-QNRC2-A03)。

摘　　要：目的:了解表观遗传学在中医证候本质研究中的应用情况。方法:检索摘要中包含"表观遗传"或"miRNA"或"DNA甲基化"或"组蛋白修饰",并含"证"的文献,检索数据库为中国知网(CNKI),检索时间为建库时间至2019年3月12日。采用Citespace进行作者和机构的共现分析;Notexpress导入文献题录并提取信息,再利用EXCEL 2016进行描述分析,包括各年份发表文献数量、文献类型、发表期刊、表观遗传机制内容、所涉及证候、证素及疾病名称、研究方法。结果:证候的表观遗传研究从2009年开始逐年递增,近3年发文量达到高峰;比较稳定的研究团队是王阶、苏式兵团队;发文量较多的核心机构是成都中医药大学、上海中医药大学中医复杂系统研究中心、湖南中医药大学、北京中医药大学;文献类型以期刊论文为主;发文数量最多的是中华中医药杂志;涉及的主要表观遗传机制是miRNA、DNA甲基化;研究最多的证候是血瘀证;涉及的主要疾病是冠心病和肿瘤;研究方法以临床试验为主。结论:基于表观遗传机制的证候本质研究虽然是热点问题,但仍处于探索阶段,研究结果尚无法作为精确判断证候的生物标志物。Objective: To understand the application of epigenetics in the study of the essence of TCM syndromes. Methods: Search abstract contained "epigenetic" or "microRNAs" or "DNA methylation" or "histone modification" and contained "evidence". The retrieval database was CNKI, and the retrieval time was from the time of building the database to March 12, 2019. Citespace was used for co-occurrence analysis of authors and institutions;Notexpress was used to import bibliographic titles and extract information, and then EXCEL 2016 was used for descriptive analysis, including the number of published documents, literature types, published journals, content of epigenetic mechanism, involved syndromes, symptoms and disease names, research methods.Results: Epigenetic studies of syndromes began in 2009 and increased year by year, reaching a peak in the last three years. WANG Jie and SU Shi-bing research teams were relatively stable research teams. Chengdu University of Chinese Medicine, Shanghai University of Chinese Medicine Complex System Research Center of Chinese Medicine, Hunan University of Chinese Medicine, Beijing University of Chinese Medicine were the core institutions with more papers. Literature types are mainly Journal papers. Chinese Journal of Traditional Chinese Medicine has the largest number of articles. The main epigenetic mechanisms involved are microRNAs and DNA methylation. The most studied syndromes are blood stasis syndrome. The main diseases involved are coronary heart disease and cancer. The research methods are mainly clinical trials. Conclusion: Although the study on the essence of syndrome based on epigenetic mechanism is a hot topic, it is still in the exploratory stage. The research results can not be used as a biomarker to accurately judge the syndrome.

关 键 词：证候本质 表观遗传 生物标志物 miRNA DNA甲基化 组蛋白修饰 文献计量 共现分析 Citespace 

分 类 号：R241[医药卫生—中医诊断学]