曲美他嗪与阿托伐他汀配合治疗对急性心梗后早期心绞痛患者的血液流变学影响研究  

Effect of trimetazidine combined with atorvastatin on hemorheology in patients with early angina pectoris after acute myocardial infarction

作　　者：杨艳 YANG Yan(Department of Cardiovascular Medicine,Hebi City People's Hospital,Hebi,Henan 458030,China)

机构地区：[1]河南省鹤壁市人民医院心血管内科,河南鹤壁458030

出　　处：《中国医学工程》2020年第4期22-25,共4页China Medical Engineering

摘　　要：目的探讨曲美他嗪联合阿托伐他汀治疗急性心肌梗死(心梗)后早期心绞痛对患者血液流变学指标的影响。方法选取该院2018年1月至2019年1月急性心梗后早期心绞痛患者74例作为研究对象,随机分为两组,给予对照组患者服用曲美他嗪,观察组患者在对照组用药的基础上同时联用阿托伐他汀。观察并记录两组用药后的临床疗效,测定血液流变学指标,统计对比两组心电图疗效,记录两组不良反应的发生。结果观察组患者的总有效率高达100%,而对照组患者单独使用曲美他嗪治疗其总有效率只有43.24%,两组比较差异有统计学意义(P<0.05);观察组在治疗前后的血浆黏度、血小板聚集率和全血黏度上的差异均具有统计学意义(P<0.05);观察组和对照组在血液流变学治疗前后比较差异具有统计学意义(P<0.05)。对照组中患者不良反应发生率为13.51%,观察组不良反应发生率为10.81%,比较差异无统计学意义(P>0.05)。结论曲美他嗪联合阿托伐他汀治疗急性心梗后早期心绞痛临床效果满意,能改善患者的血液流学变指标,并且未明显增加不良反应,值得临床推广应用。【Objective】 To investigate the effect of trimetazidine combined with atorvastatin on hemorrheology in patients with acute angina pectoris after acute myocardial infarction.【Methods】A total of 74 patients with early angina pectoris diagnosed as acute myocardial infarction in our hospital from January 2018 to January 2019 were selected as subjects. The patients were randomly divided into two groups: control group and observation group. The patients in the control group were treated with trimetazidine, while the patients in the observation group were treated with atorvastatin on the basis of the control group. The clinical efficacy grades of the two groups were observed and recorded. The blood rheology indexes were measured. The electrocardiograms of the two groups were statistically compared. The adverse reactions of the two groups were recorded. The main adverse reactions included gastrointestinal reactions, dizziness and headache.【Results】The total effective rate of the observation group was as high as100%, while the total effective rate of the control group treated with trimetazidine alone was only 43.24%. The difference between the two groups was statistically significant(P<0.05). The changes of hemorheology indexes in the two groups were observed. The differences in plasma viscosity, platelet aggregation rate and whole blood viscosity of the observation group before and after treatment were statistically significant(P<0.05). In comparison of the blood rheology between the observation group and the control group, the difference was also statistically significant(P<0.05). The total adverse reaction rate was 13.51% in the control group and 10.81% in the observation group, and there was no statistically difference between the two groups(P>0.05).【Conclusion】Trimetazidine combined with atorvastatin is effective in the treatment of early angina pectoris after acute myocardial infarction. It can significantly improve the blood rheology index of patients, and does not significantly increase the adverse

关 键 词：曲美他嗪 阿托伐他汀 急性心梗 早期心绞痛 血液流变学指标 

分 类 号：R542.22[医药卫生—心血管疾病] R541.4[医药卫生—内科学]