兰州地区健康孕妇凝血四项及D-二聚体检测结果分析  

Analysis on the results of coagulation four parameters and D-dimer in healthy pregnant women in Lanzhou

作　　者：叶萍[1] 董雪梅[1] 张翀[1] 杜晓钟[1] YE Ping;DONG Xuemei;ZHANG Chong;DU Xiaozhong(Department of Clinical Laboratory,Gansu Maternal and Child Care Hospital,Lanzhou 730050,Gansu,China)

机构地区：[1]甘肃省妇幼保健院临床检验中心,甘肃兰州730050

出　　处：《检验医学》2020年第4期334-337,共4页Laboratory Medicine

基　　金：甘肃省自然科学基金项目(18JR3RA037);甘肃省卫生行业计划项目(GSWSKY-2015-20)。

摘　　要：目的分析兰州地区不同孕期健康孕妇凝血四项及D-二聚体(DD)检测结果,为临床准确评估孕妇出凝血状态提供参考。方法对7 802名健康孕妇及168名非孕女性(非孕对照组)进行回顾性分析。按孕周将7 802名孕妇分为早孕组、中孕组、晚孕组,分析其凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)、纤维蛋白(Fib)浓度、DD的检测结果。结果随着妊娠的进展,孕妇PT、APTT、TT逐渐缩短,而Fib和DD逐渐升高。非孕对照组与妊娠期各组比较、妊娠期各组之间比较,Fib与DD差异均有统计学意义(P<0.01)。结论初步确定了兰州地区不同孕期健康孕妇凝血四项及DD的评估标准,提高了出凝血功能检测在孕妇中的临床应用价值。Objective To analyze the results of coagulation four parameters and D-dimer(DD)in healthy pregnant women with different gestational weeks in Lanzhou,and to provide a reference for assessing the status of maternal coagulation.Methods Retrospective analysis was performed in 7802 pregnant women and 168 nonpregnant women.According to different gestational weeks,7802 pregnant women were classified into early pregnancy group,middle pregnancy group and late pregnancy group.Prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(Fib)and DD were determined.Results With the progress of gestational weeks,PT,APTT and TT in pregnant women were gradually shortened,and Fib and DD were gradually increased.Compared with pregnant groups,Fib and DD had statistical significance in nonpregnant group(P<0.01).Conclusions The reference of PT,APTT,TT,Fib and DD for each pregnancy stage in Lanzhou has been established,which improves the application of maternal coagulation function determinations in clinical diagnosis.

关 键 词：D-二聚体 出凝血功能 参考区间 妊娠 

分 类 号：R446.1[医药卫生—诊断学]