米非司酮配伍米索前列醇片联合宫颈扩张在孕12-18周女性引产中的效果及对排胎时间的影响  

Effects of Mifepristone and Misoprostol Tablets Combined with Cervical Dilatation on Labor Induction of Women During 12-18 Weeks of Pregnancy and Its Influence on Fetal Discharge Time

作　　者：庞逸云 PANG Yi-yun(Department of Obstetrics and Gynecology,Xinhui District Siqian People’s Hospital,Jiangmen 529159,Guangdong Province,China)

机构地区：[1]广东省江门市新会区司前人民医院妇产科,广东江门529159

出　　处：《罕少疾病杂志》2020年第1期55-57,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探究米非司酮配伍米索前列醇片联合宫颈扩张在孕12-18周女性引产中的效果及对排胎时间的影响。方法回顾性分析江门市新会区司前人民医院妇产科自愿要求引产的140例正常孕妇(孕12-18周)资料,72例为羊膜腔内注射乳酸依沙吖啶和米非司酮方案归入对照组,68例为米非司酮配伍米索前列醇片联合宫颈扩张方案归入研究组,比较两组引产结果、清宫率、宫缩开始时间、宫缩后排胎时间、出血量及不良事件情况。结果研究组引产有效率高于对照组(98.53%vs90.28%,P<0.05),两组流产后清宫率比较差异无统计学意义(39.70%vs36.11%,P>0.05);研究组宫缩开始时间及宫缩后排胎时间均短于对照组[(4.78±2.14)hvs(31.72±11.52)h,(8.24±3.65)hvs(10.72±4.27)h,P<0.05],出血量少于对照组[(69.47±28.53)mlvs(96.32±37.26)ml,P<0.05];引产过程,研究组不良事件发生率低于对照组(14.71%vs34.94%,P<0.05)。结论孕12-18周女性选择米非司酮配伍米索前列醇片联合宫颈扩张术方案引产,可提高引产成功率,在更短时间内排胎,安全性高。Objective To explore the effects of mifepristone and misoprostol tablets combined with cervical dilatation on labor induction of women during 12 to 18 weeks of pregnancy and its influence on fetal discharge time. Methods A retrospective analysis was performed on the clinical data of 140 normal pregnant women(at 12-18 weeks of pregnancy) who asked voluntarily labor induction in department of obstetrics and gynecology of Xinhui District Siqian People’ s Hospital, Jiangmen City. And 72 cases who were given intramniotic injection of ethacridine lactate + mifepristone were included in control group, and 68 cases who were given mifepristone and misoprostol tablets combined with cervical dilatation were included into study group. The labor induction results, currettage rate, starting time of uterine contractions, fetal discharge time after uterine contractions, bleeding amount and adverse events were compared between the two groups. Results The effective rate of labor induction in study group was significantly higher than that in control group(98.53% vs 90.28%, P<0.05), and there was no significant difference in the currettage rate after abortion between the two groups(39.70% vs 36.11%, P>0.05). The starting time of uterine contractions and fetal discharge time after uterine contractions in study group were significantly shorter than those in control group [(4.78±2.14)h vs(31.72±11.52)h,(8.24±3.65)h vs(10.72±4.27)h, P<0.05], and the bleeding amount was significantly less than that in control group [(69.47±28.53)ml vs(96.32±37.26)ml, P<0.05]. The incidence rate of adverse events in study group was significantly lower than that in control group during labor induction(14.71% vs 34.94%, P<0.05). Conclusion Mifepristone and misoprostol tablets combined with cervical dilatation can improve the success rate of labor induction in the labor induction of women during 12-18 weeks of pregnancy, and it has fetal discharge in a shorter time and has high safety.

关 键 词：米非司酮 米索前列醇片 宫颈扩张术 引产 排胎时间 

分 类 号：R719.3[医药卫生—妇产科学] R453[医药卫生—临床医学]