中孕早期彩超检查结合唐氏筛查在临高龄孕妇胎儿畸形筛查中的应用价值  

The application value of color Doppler ultrasound examination in early pregnancy combined with Down’s screening in screening of fetal malformation in pregnant women

作　　者：候广霞 韩阳 尹焦 芦雪 Hou Guangxia;Han Yang;Yin Jiao;Lu Xue(Department of Ultrasound Room,Northern Theater General Hospital and Peace Branch,Shenyang,Liaoning,110003,China;Department of Ultrasound Room,Mudanjiang City Maternal and Child Health Hospital,Heilongjiang,Mudanjiang,157000,China)

机构地区：[1]北部战区总医院和平分院彩超室,辽宁沈阳110003 [2]牡丹江市妇幼保健院超声科,黑龙江牡丹江157000

出　　处：《当代医学》2020年第14期74-76,共3页Contemporary Medicine

摘　　要：目的探讨彩超检查结合唐氏综合筛查在胎儿畸形筛查中的应用价值。方法选取2015年1月至2019年1月在本院进行产前胎儿畸形筛查的82例临高龄孕妇作为研究对象,根据最终诊断结果将所有胎儿按照有无畸形分成两组,其中37例无胎儿畸形孕妇设为对照组,45例胎儿畸形孕妇设为研究组。所有孕妇均接受彩色多普勒检查和唐氏综合筛查,分析彩超检查结合唐氏综合筛查在胎儿畸形筛查中的应用价值。结果彩色多普勒超声联合唐氏综合筛查诊断胎儿畸形符合率为95.55%,明显高于单独采用彩色多普勒超声检查的80.00%,差异有统计学意义(P<0.05)。唐氏综合筛查表明,研究组人绒毛膜促性腺激素(HCG)水平(637 155.21±15 779.31)mU/mL和甲型胎儿蛋白(AFP)水平(575.32±122.46)ng/mL均明显高于对照组(321 757.32±11 943.26)mU/mL、(70.41±49.36)ng/mL,差异有统计学意义(P<0.05)。结论中孕早期彩超检查结合唐氏综合筛查应用于临高龄孕妇胎儿畸形的筛查中具有较高的诊断准确性和应用价值,值得在临床积极推广。Objective To explore the application value of color Doppler ultrasound combined with Down’ s comprehensive screening in fetal malformation screening. Methods 82 pregnant women with prenatal fetal malformation were enrolled in our hospital as the study subjects. The case data were selected from January 2015 to January 2019. According to the final diagnosis, all fetuses were divided into two group according to the presence or absence of malformation. 37 cases without fetal malformation were set as the control group, and 45 pregnant women with fetal malformation were set as the study group. All pregnant women received color Doppler examination and Down’ s comprehensive screening to analyze the application value of color Doppler ultrasound combined with Down’ s comprehensive screening in fetal malformation screening. Results Color Doppler ultrasound combined with Down’ s comprehensive screening diagnosis found that the coincidence rate of fetal malformation was 95.55%, which was significantly higher than the coincidence rate of color Doppler ultrasonography(80.00%). The difference was statistically significant(P<0.05).Down’ s comprehensive screening showed that the human chorionic gonadotropin(hCG) level(637 155.21±15 779.31) mU/mL and the alpha-fetoprotein(AFP) level(575.32±122.46) ng/mL were significantly higher in the study group than in the control group(321 757.32±11 943.26)mU/mL,(70.41±49.36) ng/mL, the difference was statistically significant(P<0.05). Conclusion In the early pregnancy, color Doppler ultrasound combined with Down’ s comprehensive screening has a high diagnostic accuracy in the screening of fetal malformations in pregnant women, and it has high application value and is worthy of active promotion in clinical practice.

关 键 词：彩色超声多普勒 唐氏综合筛查 胎儿畸形 筛查 应用价值 

分 类 号：R445.1[医药卫生—影像医学与核医学] R714.5[医药卫生—诊断学]