抗子宫内膜抗体和抗精子抗体在临床中的价值探讨  

The value of anti-endometrial antibody and anti-sperm antibody in clinical practice

作　　者：李翠[1] 段忠亮[1] 周进 张彬[1] 应春妹[1] LI Cui;DUAN Zhong-liang;ZHOU Jin;ZHANG Bin;YING Chun-mei(Obstetrics and gynecology hospital of Fudan university,Shanghai China,200011)

机构地区：[1]复旦大学附属妇产科医院,上海200011

出　　处：《中国优生与遗传杂志》2020年第1期60-62,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨抗精子抗体和抗子宫内膜抗体在临床上检测原发性不孕和复发性自然流产的价值。方法回顾性分析2018年1月至2018年12月在复旦大学附属妇产科医院诊治的原发性不孕患者及复发性自然流产患者病史,以同期进行常规检查的孕妇作为对照,对比研究对象抗子宫内膜抗体、抗精子抗体的水平,分析抗子宫内膜抗体、抗精子抗体在原发性不孕和复发性自然流产中可能的相关性。结果收集到原发性不孕患者170例及复发性自然流产患者238例病史资料,以同期进行常规检查的孕妇208例作为对照组。原发性不孕患者抗精子抗体检测阳性例数显著高于对照组,但抗子宫内膜抗体并无显著改变;复发性自然流产患者抗子宫内膜抗体检测阳性率显著高于对照组,但抗精子抗体并无明显不同;早孕期流产患者抗精子抗体检测阳性率显著高于对照组;发生复发性自然流产在4次以上的病人,其体内抗子宫内膜抗体和抗精子抗体的水平均显著高于对照组。结论抗子宫内膜抗体和抗精子抗体检测在复发性自然流产和原发性不孕患者中具有相关的临床价值,应加强备孕人群的筛查工作,及早干预。Objective:To detect the value of anti-sperm antibody and anti-endometrial antibody in primary infertility and recurrent spontaneous abortion.Methods:Retrospectively analysed the medical records of primary infertility patients and recurrent spontaneous abortion patients treated at obstetrics and gynecology hospital of Fudan University from January 2018 to December 2018,with the routine pregnant women of same period as a control.Compared the level of anti-endometrial antibody,anti-sperm antibody in different groups,and analyse the association of anti-sperm antibody and anti-endometrial antibody with primary infertility and recurrent spontaneous abortion.Results:Data on the medical records of 170 cases of primary infertility and 238 cases of recurrent natural abortion were collected,and 208 cases of pregnant women who underwent routine examination during the same period were collected.The number of positive cases of anti-sperm antibody test in patients with primary infertility was significantly higher than that of the control group,but there was no significant change in anti-endometrial antibody,the positive rate of anti-endometrial antibody in patients with recurrent spontaneous abortion was significantly higher than that of the control group,but the anti-sperm antibody was not significantly different,and the positive rate of anti-sperm antibody test in patients with early pregnancy abortion was significantly higher than that of the control group.In patients with recurrent spontaneous abortion more than 4 times,the level of anti-endometrial antibody and anti-sperm antibody in their bodies was significantly higher than that of the control group.Conclusion:Anti-endometrial antibody and anti-sperm antibody testing has relevant clinical value in patients with recurrent spontaneous abortion and primary infertility,and screening of pregnant people should be strengthened and early intervention should be strengthened.

关 键 词：抗精子抗体 抗子宫内膜抗体 复发性自然流产 原发性不孕 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]