淋球菌抵抗中性粒细胞杀伤机制研究进展  

Latest progress on neutrophil killing mechanism of Neisseria gonorrhoeae

作　　者：郑晓丽 尹跃平 周可 ZHENG Xiaoli;YIN Yueping;ZHOU Ke(Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College,National Center for STD Control,China CDC,Nanjing 210042,Jiangsu,China)

机构地区：[1]中国医学科学院北京协和医学院皮肤病医院/中国疾病预防控制中心性病控制中心,南京210042

出　　处：《中国艾滋病性病》2020年第3期327-330,共4页Chinese Journal of Aids & STD

基　　金：中国医学科学院医学与健康科技创新工程项目(2016-I2M-3-021);“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项(2018ZX10101001-004-003)。

摘　　要：淋球菌为引起淋病的致病菌,其侵入人体可引发强烈的局部免疫反应,诱导中性粒细胞募集至感染部位,但是中性粒细胞不能完全清除该菌。淋球菌可通过诸多机制逃逸中性粒细胞的吞噬、抑制吞噬体成熟,抵抗氧化杀伤、非氧化杀伤及胞外诱捕网杀伤等。本文主要综述淋球菌逃逸中性粒细胞杀伤的具体机制,为淋球菌的致病机制研究、疫苗研制以及抗菌药物靶点提供新的思路。Neisseria gonorrhoeae is the pathogen of gonorrhea. It can invade the human body and induce intense local immune response. It induces the recruitment of neutrophils to the infected site, but neutrophils cannot completely eliminate the bacteria. Neisseria gonorrhoeae can escape phagocytosis, limit neutrophil phagosome maturation, and resist oxidative killing, non-oxidative killing and neutrophil extracellular traps killing of neutrophils through many mechanisms. This review mainly describes the specific mechanism of neutrophil killing by Neisseria gonorrhoeae, and provides new ideas for the pathogenesis of Neisseria gonorrhoeae, vaccine development and antibiotic targets.

关 键 词：淋球菌 中性粒细胞 抵抗 吞噬 杀伤 

分 类 号：R759[医药卫生—皮肤病学与性病学]