急性心梗患者应用阿替普酶与尿激酶静脉溶栓对血流动力学状态的影响比较  

Comparison of Effects of Alteplase and Urokinase Intravenous Thrombolysis on Hemodynamic Status in Patients with Acute Myocardial Infarction

作　　者：陈亚君 乔雯雯 CHEN Ya-jun;QIAO Wen-wen(Department of Cardiology,the First Affiliated Hospital of Henan Polytechnic University,Jiaozuo Second People's Hospital,Jiaozuo 454000,Henan province,China)

机构地区：[1]河南理工大学第一附属医院(焦作市第二人民医院)心内科,河南焦作454000

出　　处：《罕少疾病杂志》2020年第2期1-2,5,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的研究比较急性心梗患者应用阿替普酶与尿激酶静脉溶栓对血流动力学状态的影响。方法运用随机数表法将本院2017年1月~2019年3月诊治的94例急性心梗患者分为观察组与对照组,各47例。对照组采用尿激素静脉溶栓治疗方法,观察组采用阿替普酶进行治疗。结果观察组治疗后ESR、Fb、nbl、nbh血液动力学指标均比对照组低(P<0.05);观察组患者在60min、90min、120min的血管再通率均比对照组显著高(P<0.05),观察组患者在30min的血管再通率比对照组高(P>0.05);观察组患者心率失常、心率衰竭、再梗死、休克、出血、心脏破裂不良反应发生率比对照组低(P>0.05)。结论对于急性心梗患者,阿替普酶相比尿激酶静脉溶栓可以更好改善血流动力学,增加血管再通率,减少不良反应,值得应用推广。Objective To study and compare the effects of alteplase and urokinase intravenous thrombolysis on hemodynamic status in patients with acute myocardial infarction. Methods 94 patients with acute myocardial infarction who were treated in the hospital from January 2017 to March 2019 were divided into observation group and control group according to the random number table method, with 47 cases in each group. Control group was treated with intravenous thrombolysis with urinary hormones, and observation group was treated with alteplase. Results The hemodynamic parameters of ESR, Fb, nbl and nbh in observation group were lower than those in control group(P<0.05). The recanalization rate in observation group at 60 min, 90 min and 120 min was significantly higher than that in control group(P<0.05), and the recanalization rate at 30 min in observation group was higher than that in control group(P>0.05). The incidence rates of adverse reactions of arrhythmia, heart failure, reinfarction, shock, hemorrhage and cardiac rupture in observation group were lower than those in control group(P>0.05). Conclusion For patients with acute myocardial infarction, alteplase can improve hemodynamics, increase blood vessel recanalization rate and reduce adverse reactions compared with urokinase intravenous thrombolysis. Thus it is worthy of application and promotion.

关 键 词：急性心梗患者 阿替普酶 尿激酶 血流动力学 

分 类 号：R542.22[医药卫生—心血管疾病]