理气化湿活血汤联合拉米夫定治疗慢性乙型肝炎的效果及对HBV-DNA病毒载量的影响  

Effects of Liqi Huashi Huoxue Decoction Combined with Lamivudine on Chronic Hepatitis B and its Influence on HBV-DNA Viral Load

作　　者：王立坤 翟玉峰[1] 朱喜增[1] 李哲 WANG Li-kun;ZHAI Yu-feng;ZHU Zeng-xi(Department of Infection,Nanyang Central Hospital,nanyang 473000,Henan Province,China)

机构地区：[1]河南省南阳市中心医院感染科,河南南阳473000

出　　处：《罕少疾病杂志》2020年第2期38-40,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探究理气化湿活血汤联合拉米夫定治疗慢性乙型肝炎的效果及对乙型肝炎病毒脱氧核糖核酸(HBV-DNA)病毒载量的影响。方法选取2017年2月~2018年2月于我院接受治疗的82例慢性乙型肝炎患者为受试对象,按照入院顺序随机分为研究组与对照组各41例。对照组予以恩替卡韦治疗,研究组给予理气化湿活血汤联合拉米夫定治疗。比较两组患者治疗6个月后肝功能[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、直接胆红素(DBIL)、总胆红素(TBIL)]水平、治疗情况[HBeAg转阴率、血清丙氨酸氨基转移酶(ALT)复常率],比较两组患者治疗2、4、6个月后HBV-DNA病毒载量。结果治疗6个月后,研究组患者ALT、AST、DBIL、TBIL水平均明显低于对照组,研究组HBeAg转阴率及ALT复常率均明显高于对照组,治疗2、4、6个月的时候,研究组HBV-DNA病毒载量水平均明显低于对照组(P均<0.05)。结论理气化湿活血汤联合拉米夫定能够有效降低慢性乙型肝炎患者的HBV-DNA病毒载量、改善肝功能,疗效较好。Objective To explore the effects of Liqi Huashi Huoxue decoction combined with lamivudine in the treatment of chronic hepatitis B and its influence on viral load of hepatitis B virus-desoxyribonucleic acid(HBV-DNA). Methods Eighty-two patients with chronic hepatitis B who were treated in our hospital from February 2017 to February 2018 were selected for the study and were randomly divided into study group and control group according to the admission sequence, with 41 cases in each group. Control group was treated with entecavir, and study group was treated with Liqi Huashi Huoxue decoction combined with lamivudine. The indexes of liver function [alanine aminotransferase(ALT), aspartate aminotransferase(AST), direct bilirubin(DBIL), total bilirubin(TBIL)] and treatment status [HBeAg negative conversion rate, serum alanine aminotransferase(ALT) recovery rate]were compared between the two groups after 6 months of treatment, and the HBV-DNA viral load after 2, 4 and 6 months of treatment was compared between the two groups.Results After 6 months of treatment, the levels of ALT, AST, DBIL and TBIL in study group were significantly lower than those in control group, and the HBeAg negative conversion rate and ALT recovery rate instudy group were significantly higher than those in control group, and the HBV-DNA viral load level in study group at 2, 4 and 6 months of treatment was significantly lower than that in control group(P<0.05). Conclusion Liqi Huashi Huoxue decoction combined with lamivudine can effectively reduce the HBV-DNA viral load and improve liver function in patients with chronic hepatitis B, with good efficacy.

关 键 词：理气化湿活血汤 拉米夫定 慢性乙型肝炎 HBV-DNA病毒载量 

分 类 号：R512.62[医药卫生—内科学]