接骨续筋胶囊对胫骨骨折患者骨愈合进程及血清TGF-β_1水平的影响分析  

Effects of Jiegu Xujin Capsule on Bone Healing Process and Serum TGF-β_1 Level in Patients with Tibial Fractures

作　　者：孙雨锋[1] 韦中阳[1] 韦宇霞 SUN Yu-feng;WEI Zhong-yang;WEI Yu-xia(Department of Orthopedics,The People's Hospital of Anyang City,Anyang 455000,Henan Province,China)

机构地区：[1]河南省安阳市人民医院骨科,河南安阳455000 [2]河南省安阳职业技术学院,河南安阳455000

出　　处：《罕少疾病杂志》2020年第2期64-66,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的研究接骨续筋胶囊对胫骨骨折患者骨愈合进程及血清转化生长因子-β_1(TGF-β_1)水平的影响。方法随机数表法将本院2016年1月~2018年8月诊治的60例胫骨骨折患者分为观察组与对照组,各30例,两组患者均给予交锁髓内钉固定术治疗,对照组术后给予石膏固定,观察组在对照组的基础上给予口服接骨续筋胶囊治疗。观察并比较两组患者骨愈合进程,并检测不同时间段血清TGF-β_1的变化。结果观察组X线片骨折线消失时间、骨折愈合时间以及术后一周VAS评分均明显低于对照组,术后1个月Lysholm评分明显高于对照组(P<0.05);两组患者血清TGF-β_1水平术后0d无明显差异,术后14、28、60d血清TGF-β_1水平明显高于对照组(P<0.05)。结论接骨续筋胶囊应用于胫骨骨折患者可有效提高血清TGF-β_1水平,缩短骨折愈合时间,促进膝关节功能恢复。Objective To study the effects of Jiegu Xujin capsule on bone healing process and serum transforming growth factor-β_1(TGF-β_1) level in patients with tibiofibular fractures. Methods A random number table method was used to classify 60 patients with tibial fractures from January 2016 to August 2018 in our hospital into observation group and control group, with 30 cases in each group. The two groups were treated with intramedullary nail fixation, and control group was treated with cast immobilization after operation, and observation group was given oral Jiegu Xujin capsule on the basis of control group. The bone healing process was observed and compared between the two groups, and the changes of serum TGF-β_1 were detected at different time points. Results The disappearance time of X-ray fracture line, fracture healing time and VAS score in observation group were significantly lower than those in control group, and the Lysholm score was significantly higher than that in control group at 1 month after operation(P<0.05). There was no significant difference in the serum TGF-β_1 level between the two groups at 0 d after operation, and the level of serum TGF-β_1 at 14, 28 and 60 d after operation was significantly higher than that in control group(P<0.05). Conclusion Jiegu Xujin capsule can effectively improve serum TGF-β_1 level, shorten fracture healing time and promote knee joint function recovery in patients with tibial fractures.

关 键 词：接骨续筋胶囊 胫骨骨折 骨愈合进程 转化生长因子-β_1 

分 类 号：R683[医药卫生—骨科学] R274.1[医药卫生—外科学]