BMI与宫颈癌发病风险的Meta分析  

Meta-analysis of BMI and risk of cervical cancer

作　　者：王霄玲 朱洁云 李柏成 罗毅沣[2] 钟枝梅 李倩 张剑锋[2] WANG Xiao-ling;ZHU Jie-yun;LI Bai-cheng;LUO Yi-feng;ZHONG Zhi-mei;LI Qian;ZHANG Jian-feng(Graduate School of Guangxi Medical University,Nanning,Guangxi 530007,China;不详)

机构地区：[1]广西医科大学研究生院,广西南宁530007 [2]广西医科大学第二附属医院急诊科,广西南宁530007

出　　处：《现代预防医学》2020年第8期1393-1398,共6页Modern Preventive Medicine

基　　金：国家自然科学基金(81360290);2017年度广西高等教育本科教学改革工程立项项目(2017JGA159)。

摘　　要：目的探讨BMI与宫颈癌发病风险的关系。方法采用系统评价方法,在EMbase、The Cochrane Library、PubMed、CNKI、Wan Fang Data和VIP数据库上,检索BMI与宫颈癌发病关系的文献,检索时限均从建库至2019年5月,整个过程由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险,采用Stata 12.0软件进行Meta分析。结果共纳入15个研究,共计1 178 773名研究对象。Meta分析结果显示:超重人群患宫颈癌的风险是正常体重人群的1.10倍(OR=1.10,95%CI:1.04~1.16,P=0.001),肥胖人群患宫颈癌的风险是正常体重人群的1.34倍(OR=1.34,95%CI:1.16~1.55,P<0.001),差异均有统计学意义。结论超重和肥胖均会增加宫颈癌发病风险,超重与宫颈癌发病风险之间的相关性较弱,但肥胖与宫颈癌发病风险之间有显著的相关性。Objective To explore the relationship between BMI and risk of cervical cancer. Methods Using systematic review methods to search the literature on the relationship between BMI and cervical cancer in EMbase, the Cochrane Library,PubMed, CNKI, WanFang Data, and VIP database. The retrieval time was from database construction to May 2019. In the whole process, two researchers independently screened the literature, extracted the data and evaluated the bias risk of inclusion in the study. Meta-analysis was carried out by Stata12.0 software. Results A total of 15 studies were included with1 178 773 subjects. Meta-analysis showed that the risk of cervical cancer in overweight people was 1.10 times that of normal weight [OR=1.10, 95% CI:(1.04-1.16),P=0.001], and the risk of cervical cancer in obese people was 1.34 times [OR=1.34, 95% CI:(1.16-1.55), P <0.001], the difference was statistically significant. Conclusion Both overweight and obesity increased the risk of cervical cancer. The correlation between overweight and cervical cancer risk was weak, but there was a significant correlation between obesity and cervical cancer risk.

关 键 词：宫颈癌 体重指数 META分析 

分 类 号：R711.74[医药卫生—妇产科学]