血清谷丙转氨酶水平与不同性别2型糖尿病患病的关系  

Association of serum alanine aminotransferase level and type 2 diabetes mellitus in different genders

作　　者：张金连 苑东敏 崔静 赵园园 王云云 杨帆[1] 孙健平[1,3,4] ZHANG Jin-lian;YUAN Dong-min;CUI Jing;ZHAO Yuan-yuan;WANG Yun-yun;YANG Fan;SUN Jian-pin(Nutrition and Food Hygiene,School of Public Health,Qingdao University,Qingdao,Shandong 266021,China;不详)

机构地区：[1]青岛大学公共卫生学院营养与食品卫生学,山东青岛266021 [2]平邑县人民医院眼科,山东临沂273300 [3]潍坊医学院公共卫生与管理学院,山东潍坊261053 [4]青岛市疾病预防控制中心,青岛市预防医学研究院,山东青岛266033

出　　处：《现代预防医学》2020年第8期1514-1518,共5页Modern Preventive Medicine

基　　金：青岛糖尿病预防项目(WDF05-108、WDF07-308);青岛市2017年度医药科研指导计划(2017-WJZD129);青岛市医疗卫生优秀人才培养项目;青岛市科技局立项(19-6-1-5-nsh)。

摘　　要：目的探讨血清谷丙转氨酶(ALT)与新诊2型糖尿病(T2DM)患病风险之间的关联,为T2DM的防治提供科学依据。方法采用4阶段分层随机抽样的方法选取2006年和2009年参与青岛糖尿病预防项目的研究对象男性3 012例、女性4 422例,采用Pearson相关检验分析不同性别ALT与FPG、2 h PG的相关性,并利用多因素logistic回归分析ALT与新诊T2DM患病的关系。结果男性中,ALT与空腹血浆血糖(FPG)、餐后2 h血浆血糖(2 h PG)的Pearson相关系数分别为0.088、0.080(均P<0.01);多因素logistic回归显示,在调整了年龄、BMI、糖尿病家族史、城乡、教育、婚姻、收入、吸烟及饮酒状况等混杂因素后,ALT的第4分位(Q4)组新诊T2DM患病风险是第1分位(Q1)组的1.832倍(OR=1.832,95%CI:1.324~2.534,P<0.01)。女性中,ALT与FPG、2h PG的Pearson相关系数分别为0.065、0.108(均P<0.01);多因素logistic回归显示,在调整了年龄、BMI、糖尿病家族史、城乡、教育、婚姻、收入、吸烟及饮酒状况等混杂因素后,ALT的第4分位(Q4)组新诊T2DM患病风险是第1分位(Q1)组的1.445倍(OR=1.445,95%CI:1.087~1.919,P<0.05)。结论在男、女性人群中,ALT水平升高与T2DM患病相关,且这种相关性不受年龄、BMI、糖尿病家族史等的影响。Objective The aim of this study was to investigate the association of serum alanine aminotransferase(ALT) and the risk of newly diagnosed type 2 diabetes(T2 DM), and thus to provide a scientific basis for the prevention and treatment of T2 DM. Methods 3 012 male and 4 422 female, participated in Qingdao diabetes prevention project, were selected in 2006 and 2009 by four-stage stratified random sampling. Pearson correlation test was used to analyze the correlation between ALT and fasting plasma glucose(FPG), and 2 h post-load plasma glucose(2 h PG). Multivariate logistic regression was used to analyze the association of ALT and newly diagnosed T2DM. Results For male, the Pearson correlation coefficients of ALT and FPG, 2 h PG were 0.088 and 0.080(P both<0.01), respectively. Multivariate logistic regression showed that the risk of newly diagnosed T2DM in the Q4 group of ALT was 1.832 times(OR=1.832, 95% CI: 1.324-2.534) higher than that in the Q1 group. For female,the Pearson correlation coefficients of ALT and FPG, and 2 h PG were 0.065 and 0.108(P both<0.01), respectively. Multivariate logistic regression showed that the risk of newly diagnosed T2DM in the Q4 group of ALT was 1.445 times(OR=1.445, 95% CI:1.087-1.919) higher than that in the Q1 group. Conclusion Elevated ALT levels were associated with the risk of T2DM in male and female populations, and this association was not affected by age, BMI, and family history of diabetes and so on.

关 键 词：谷丙转氨酶 2型糖尿病 相关性 

分 类 号：R446[医药卫生—诊断学]