基于分子印迹的荧光传感技术及其应用研究  

Advances of molecular imprinted fluorescence sensing technology and its applications

作　　者：韩笑笑 齐骥 宋志花 石雅君[2] 刘丰 张昱 韩京龙[1] 徐惠忠[1] 李博伟[2] Xiaoxiao Han;Ji Qi;Zhihua Song;Yajun Shi;Feng Liu;Yu Zhang;Jinglong Han;Huizhong Xu;Bowei Li(School of Environment and Materials Engineering,Yantai University,Yantai 264005,China;CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation,Research Center for Coastal Environmental Engineering and Technology,Yantai Institute of Coastal Zone Research,Chinese Academy of Sciences,Yantai 264003,China;School of Pharmacy,Key Laboratory of Molecular Pharmacology and Drug Evaluation(Yantai University),Ministry of Education,Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugsin Universities of Shandong,Yantai University,Yantai 264005,China)

机构地区：[1]烟台大学环境与材料工程学院,烟台264005 [2]中国科学院烟台海岸带研究所海岸带环境过程与生态修复重点实验室,山东省海岸带环境工程技术研究中心,烟台264003 [3]烟台大学药学院,分子药理和药物评价教育部重点实验室,新型制剂与生物技术药物研究山东省高校协同创新中心,烟台264005

出　　处：《中国科学：化学》2020年第4期463-475,共13页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:41776110)资助项目。

摘　　要：分子印迹技术(molecular imprinting technology, MIT)是针对某一特定模板分子制备具有特异选择性印迹聚合物(molecularly imprinted polymer, MIPs)的技术.以MIPs为分子识别元件,结合高度灵敏的荧光检测构建分子印迹荧光传感器(molecular imprinting-based fluorescence sensors, MI-FL sensors)在环境有机污染物的痕量检测领域备受关注.根据荧光发射信号的不同表达模式,本文介绍了多种不同分子印迹荧光传感器的构建策略和对环境中农药残留、雌激素、抗生素等有机污染物的检测应用,并展望了其面临的机遇与挑战.Molecular imprinting is a technique to synthesize molecularly imprinted polymers(MIPs) with specific and selective recognition ability for a given template molecule. As a molecular recognition component, MIPs combined with highly sensitive fluorescent detection to construct molecular imprinting-based fluorescence sensors(MI-FL sensors),which have attracted much attention in the field of trace detection of environmental organic pollutants. According to the expression of fluorescence emission signal, this review introduces the various strategies for MI-FL sensors. The applications of MI-FL sensors in pesticide residues, estrogen, and antibiotic in the environment are described briefly,and the challenges and development are prospected.

关 键 词：分子印迹荧光传感器 单发射型 比率型 农药残留 雌激素 抗生素 

分 类 号：X830[环境科学与工程—环境工程] O657.3[理学—分析化学]