缺氧诱导因子1在支气管哮喘气道炎症机制中的研究进展  

Research in hypoxia inducible factor-1 and airway inflammation of bronchial asthma

作　　者：梁丽霞 朱黎明[2] 曾丹[3] 戴爱国 Liang Lixia;Zhu Liming;Zeng Dan;Dai Aiguo(Department of Respiratory and Critical Care Medicine,the Affiliated Nanhua Hospital,University of South China,Hengyang 421002,China;Department of Respiratory Medicine,Hunan Provincial People’s Hospital,Changsha 410016,China;Institute of Respiratory Disease,Hunan Provincial People's Hospital,Changsha 410016,China;Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]南华大学附属南华医院呼吸与危重症医学科,衡阳421002 [2]湖南省人民医院呼吸内科,长沙410016 [3]湖南省人民医院呼吸疾病研究所,长沙410016 [4]湖南中医药大学,长沙410208

出　　处：《国际呼吸杂志》2020年第8期613-618,共6页International Journal of Respiration

基　　金：国家自然科学基金(81270093);湖南省医药卫生科研计划项目(B2013-063)。

摘　　要：缺氧诱导因子1(HIF-1)是由α亚基和β亚基构成的异二聚体缺氧反应转录因子,可调节100多种基因的表达,参与机体的免疫反应、细胞代谢、诱导新生血管形成等过程,并通过多种途径引起支气管哮喘气道炎症反应.本文将以此为切入点,对HIF-1在支气管哮喘气道炎症反应机制中的研究作一综述.Hypoxia-inducible factor 1(HIF-1)is a heterodimer composed of an α subunit and aβ subunit.It acts as a transcription factor that,in response to hypoxia,regulates expression of over 100 genes,including those involved in immune response,cell metabolism,neovascularization,etc.HIF-1 has also been reported to regulate the airway inflammation involved in asthma through several pathways,which represents the subject of this review.

关 键 词：哮喘 缺氧诱导因子1 气道炎症 

分 类 号：R5[医药卫生—内科学]