脂溶性维生素A、D、E与妊娠期糖尿病的相关性分析  

Correlative analysis between Fat-soluble vitamins A,D and E and Gestational Diabetes

作　　者：宋丹[1] 路旭宏 胡向红 冯奥[1] 刘丹 吕薇 李程 SONG Dan;LU Xu-hong;HU Xiang-hong;FENG Ao;LIU Dan;LV Wei;LI Cheng(Obstetrics,The Affiliated Zhongshan Hospital of Dalian University,Dalian,Liaoning,116001,China)

机构地区：[1]大连大学附属中山医院,辽宁大连116001

出　　处：《现代生物医学进展》2020年第1期115-117,139,共4页Progress in Modern Biomedicine

基　　金：国家卫生和计划生育委员会医药卫生科技发展中心项目(W2015CAE127)。

摘　　要：目的:探讨妊娠期糖尿病(gestational diabetes mellitus,GDM)孕妇血清中维生素A、25-羟基维生素D、维生素E的水平及其临床意义。方法:选取在大连大学附属中山医院就诊并诊断为GDM的孕妇1000例为实验组;另选取无GDM孕妇1000例为对照组。采用反向高频液相色谱荧光法(high-performance liquid chromatography,HPLC)测定其血清维生素A、E水平;高效液相色谱液相色谱串联质谱法(high-performance liquid chromatography tandem mass spectrometer,HPLC-AS/MS)测定血清25-羟基维生素D水平。结果:GDM孕妇血清中维生素A水平与无GDM孕妇比较差异无统计学意义(P>0.05);GDM孕妇血清25-羟基维生素D水平明显低于对照组(P<0.05);GDM孕妇血清维生素E水平明显高于对照组(P<0.05)。GDM孕妇血清25-羟基维生素D水平与血清维生素E水平呈显著负相关(r=-0.351,P<0.05)。结论:GDM孕妇血清25-羟基维生素D水平低,维生素E水平高,且两者有一定相关性,可能共同参与了GDM的发生。Objective:To investigate the expression levels and clinical significance of vitamin A,25-hydroxyvitamin D,vitamin E in pregnant women with gestational diabetes mellitus.Methods:One hundred patients with GDM diagnosed in Zhongshan Hospital Affiliated to Dalian University were selected as experimental group;100 non-GDM patients were selected as control group.High-performance liquid chromatography(HPLC)was used to determine vitamin A and E levels;high-performance liquid chromatography tandem mass spectrometer(HPLC-AS/MS)was used to determine 25-hydroxyvitamin D levels.Results:There was no significant difference in serum vitamin A levels between GDM patients and non-GDM patients(P>0.05);the serum 25-hydroxyvitamin D levels in GDM patients were significantly lower than those in the control group(P<0.05);the serum vitamin E levels in GDM patients were significantly higher than those in the control group(P<0.05).The serum level of 25-hydroxyvitamin D in patients with GDM was negatively correlated with the expression of vitamin E(r=-0.351,P<0.05).Conclusion:The level of 25-hydroxyvitamin D in patients with GDM is low,and the level of vitamin E is high,and there is a certain correlation between the two,and they may jointly participate in the development of GDM.

关 键 词：妊娠期糖尿病 维生素A 25-羟基维生素D 维生素E 

分 类 号：R714.256[医药卫生—妇产科学] Q56[医药卫生—临床医学]