基于QLICD-DM(V2.0)量表的糖尿病患者最小临床重要性差值的制定  

Formulation of minimal clinically important difference value of diabetic based on QLICD-DM( V2. 0) scale

作　　者：周佳丽 张晴晴 杨铮 万崇华 黄新萍 吴钧俊 沈方力 ZHOU Jia-li;ZHANG Qing-qing;YANG Zheng;WAN Chong-hua;HUANG Xin-ping;WU Jun-jun;SHEN Fang-li(Public Health School of Guangdong Medical University,Dongguan Guangdong 523808,China;Shandong Provincial Hospital,Jinan Shandong 250021,China;Humanity and Management School of Guangdong Medical University/QOL and Practical Psychology Research Center,Dongguan Guangdong 523808,China;Dongguan Shilongboai Hospital of Guangdong Proirtcc,Dongguan Guangdong 523320,China;Dongguan Dalang Hospital of Guangdong Provincc,Dongguan Guangdong 523770,China;ShanghaiBaoihan DiiysicyCDC,Shanghai 201900,China)

机构地区：[1]广东医科大学公共卫生学院,广东东莞523808 [2]山东省立医院统计与病案管理科,山东济南250021 [3]广东医科大学人文与管理学院/生命质量与应用心理研究中心,广东东莞523808 [4]广东省东莞市石龙博爱医院,广东东莞523320 [5]广东省东莞市大朗医院,广东东莞523770 [6]上海市宝山区疾病预防控制中心,上海201900

出　　处：《卫生软科学》2020年第5期19-22,共4页Soft Science of Health

基　　金：国家自然科学基金:慢性病患者报告结局测定量表体系研制及其得分的最小临床有意义差异制定(71373058);国家自然科学基金:慢性病患者生命质量测定量表体系的进一步研究与应用(30860248)。

摘　　要：[目的]制定糖尿病患者生命质量测定量表QLICD-DM(V2.0)的最小临床重要性差值(Minimal Clinical Important Difference,MCID)。[方法]采用慢性病患者生命质量测定量表体系之糖尿病量表QLICD-DM(V2.0)及SF-36量表对154名糖尿病患者进行问卷调查,分别采用以锚为基础和以分布为基础的研究方法制定最小临床重要性差值,分析比较取平均值法、取小值法和取大值法制定的最小临床重要性差值。[结果]取平均值法得到的生理功能、心理功能、社会功能、共性模块、特异模块和量表总分的MCID为5.05、5.73、3.88、4.73、6.18和5.20;取小值法得到各领域的MCID分别为3.95、2.21、0.41、3.09、3.56和3.68;取大值法得到的各领域MCID分别为6.14、9.24、7.34、6.37、8.80和6.72。[结论]三种方法计算的MCID,在心理功能、社会功能领域相差较大,而其他领域中相差较小。最终以取平均值法的结果作为QLICD-DM(V2.0)的MCID,为应用生命质量判断糖尿病患者的临床疗效提供参考依据,解决仅通过P值解释结果的局限性。Objective Formulate the minimal clinical important difference value( MCID) of Quality of Life( QOL) scale( QLICD-DM V2. 0) for diabetics. Methods 154 diabetics were investigated by QLICD-DM V2. 0 and SF-36 scale of Quality of chronic patients QOL scale. The data was used to formulate its minimal clinical important difference value on anchor-based and distribution-based research methods. Analyzed and compared the minimum clinical importance difference value which calculated by mean value,small value and large value method. Results The MCID of physical,psychological and social function,general and specific module and scale total score obtained by averaging method was 5. 05,5. 73,3. 88,4. 73,6. 18 and 5. 20 respectively,the MCID of each domain obtained by small value method was3. 95,2. 21,0. 41,3. 09,3. 56 and 3. 68 respectively,the MCIDs of each domain obtained by large value method was 6. 14,9. 24,7. 34,6. 37,8. 80,and 6. 72 respectively. Conclusions The MCID calculated by three methods which has large difference in the domains of psychological function and social function,while the difference in other domains is small. Finally,the MCID of QLICD-DM( V2. 0) results by averaging method in order to provide reference for the application of that quality of life judge clinical efficacy of diabetic,and solves the limitation of interpreting results only by P values.

关 键 词：糖尿病 生命质量 最小临床重要性差值 

分 类 号：R195[医药卫生—卫生统计学]