外周血HBP,IL-6,CD64指数,PCT,CRP和SAA水平检测在血流感染诊断中的应用价值研究  

Application Value of Peripheral Blood HBP, Interleukin-6, CD64 Index, PCT, CRP,SAA Level Detection in Blood Stream Infection Diagnosis

作　　者：任继欣 郭彦言[2] REN Ji-xin;GUO Yan-yan(Department of Clinical Laboratory,Tradilional Chinese Medicine Hospital of Fengrun District in Tangshan City,HebeiTangshan 064000,China;Department of Clinical Laboratory,Tangshan Works Hospital,Hebei Tangshan 063000,China)

机构地区：[1]唐山市丰润区中医医院检验科,河北唐山064000 [2]唐山市工人医院检验科,河北唐山063000

出　　处：《现代检验医学杂志》2020年第2期56-59,共4页Journal of Modern Laboratory Medicine

摘　　要：目的分析比较外周血中肝素结合蛋白(HBP)、白介素-6(IL-6)、中性粒细胞CD64指数、降钙素原(PCT)、C反应蛋白(CRP)和血清淀粉样蛋白A(SAA)在血流感染(bloodstreaminfection,BSI)诊断中尤其在感染早期的诊断价值。方法收集2018年度血培养阳性并确诊为血流感染的患者95例,将其分为两组:细菌感染组75例,真菌感染组20例,并选取健康体检者100例作为对照组,分别测定三组的HBP,IL-6,CD64指数,PCT,CRP和SAA水平。结果与健康对照组比较,血流感染组HBP,IL-6,CD64指数,PCT,CRP和SAA浓度水平显著性升高,差异均有统计学意义(t=6.14~14.61,均P <0.01)。与真菌感染组比较,细菌感染组各指标浓度水平升高,差异均有统计学意义(t=8.39~15.72,均P <0.01);HBP,IL-6,CD64指数,PCT,CRP,SAA诊断血流感染的AUC分别为0.903,0.813,0.798,0.856,0.751和0.822,相比较诊断价值最佳的依次是:HBP,PCT,SAA,IL-6,CD64指数和CRP。结论外周血多种因子在血流感染中均具有一定的诊断价值,在血流感染的早期以HBP, PCT,SAA的敏感度和特异度较好,诊断价值较高。Objective The analysis compared the diagnostic value of heparin binding protein(HBP), interleukin-6(IL-6), neutrophil CD64 index, procalcitonin(PCT), C reactive protein(CRP), and serum amyloid amyloid aloid(SAA) in the diagnosis of blood stream infection, especially in the early stage seismoids. Methods Collected 95 cases of blood culture positive in 2018 and diagnosed as blood stream infection, divided into two groups: 75 cases of bacterial infection group, 20 cases of fungal infection group, and selected 100 cases of health checkers as a control group, respectively, to determine three groups of HBP, IL-6, CD64 index, PCT, CRP and SAA level. Results Compared with the healthy control group, the blood stream infection group(bacteria and fungi) HBP, IL-6, CD64, PCT, CRP and SAA concentration levels increased, the difference was statistically significant(t=6.14~14.61, all P< 0.01).Compared with the fungal blood stream infection group, the concentration level of bacterial blood stream infection group increased, and the difference was statistically significant(t=8.39~15.72, all P< 0.01). HBP,IL-6,CD 64 index,PCT,CRP,and SAA diagnosis of blood stream infection AUC was 0.903,0.813,0.798,0.856,0.751 and 0.822.The best comparison of diagnostic value is in turn HBP, PCT,SAA,IL-6,CD64 index and CRP.Conclusion A variety of inflammatory factors in blood stream infection have a certain diagnostic value, in the early stage of blood stream infection, with HBP, PCT, SAA sensitivity and specificity of the best, diagnostic value is the highest.

关 键 词：肝素结合蛋白 白介素-6 降钙素原 C反应蛋白 血流感染 

分 类 号：R631[医药卫生—外科学] R446.11[医药卫生—临床医学]