2型糖尿病并发冠心病患者血清FSTL1与cTnT、BNP浓度和冠状动脉病变程度的关系  

Relationship between serum concentrations of FSTL1,cTnT,BNP and severity of coronary artery disease in patients with type 2 diabetes and coronary heart disease

作　　者：郝兰香 毕建华 黄飞 胥柯 张建[2] 刘艳梅 HAO Lan-xiang;BI Jian-hua;HUANG Fei;XU Ke;ZHANG Jian;LIU Yan-mei(Department of Endocrinology,Yancheng First People′s Hospital,Yancheng,Jiangsu 271000,China)

机构地区：[1]盐城市第一人民医院内分泌科,江苏盐城271000 [2]泰安市中心医院内分泌科,山东泰安271000

出　　处：《岭南心血管病杂志》2020年第2期152-156,共5页South China Journal of Cardiovascular Diseases

基　　金：糖尿病视网膜病变患者CD4+CD25+Foxp3+细胞与VCAM-1,ICAM-1的变化及临床意义(项目编号:YK2016004);FSTL1、BNP与2型糖尿病心肌病的相关性及血脂干预后的变化(项目编号:YK2017016)。

摘　　要：目的探讨2型糖尿病(type 2 diabetes,T2DM)并发冠状动脉粥样硬化性心脏病冠心病(coronary heart disease,CHD)患者血清卵泡抑素样蛋白-1(follistatin-like protein-1,FSTL1)、肌钙蛋白T(troponin T,c TnT)、血清B型钠尿肽(B-type natriuretic peptide,BNP)的浓度变化与冠状动脉病变程度的关系。方法选取盐城市第一人民医院2016年1月至2018年6月确诊的单纯T2DM患者90例作为T2DM组、T2DM并发CHD患者90例作为并发组、同期健康体检对象90名作为对照组。检测3组受试者的血清FSTL1、cTnT、BNP浓度,分析并发组不同冠状动脉病变支数亚组的患者血清FSTL1、c TnT、BNP浓度差异;分别采用简单线性相关及多元线性回归法分析血清FSTL1、cTnT、BNP浓度与Gensini评分的关系。结果并发组和T2DM组三酰甘油(triacylglycerol,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、空腹血糖(fasting blood glucose,FPG)浓度均高于对照组,高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)浓度低于对照组,差异有统计学意义(P<0.05)。并发组血清TG、TC、LDL-C、FPG浓度均高于T2DM组,HDL-C浓度低于T2DM组,差异有统计学意义(P<0.05)。并发组和T2DM组血清FSTL1、c TnT、BNP浓度及Gensini评分均高于对照组,差异有统计学意义(P<0.05);并发组的血清FSTL1、cTnT、BNP浓度及Gensini评分均高于T2DM组,差异有统计学意义(P<0.05)。T2DM并发CHD组患者中,三支病变亚组、双支病变亚组的血清FSTL1、cTnT、BNP浓度高于单支病变亚组,差异有统计学意义(P<0.05);三支病变亚组的血清FSTL1、c TnT、BNP浓度高于双支病变亚组,差异有统计学意义(P<0.05)。T2DM并发CHD组患者血清FSTL1、c TnT、BNP浓度与Gensini评分呈显著的正相关关系(P<0.05)。多元线性回归分析结果显示血清FSTL1、c TnT、TG、BNP浓度升高、HDL-C浓度降低是T2DM并发CHD组患者冠状动脉病变程度加重的独Objectives To investigate the relationship between the changes of serum concentrations of follistatin-likeprotein-1(FSTL1),troponin T(c Tn T),B-type natriuretic peptide(BNP)and the degree of coronary artery diseasein patients with type 2 diabetes(T2 DM)combined with coronary heart disease(CHD).MethodsTotally 90 patientsdiagnosed T2 DM were selected as T2 DM group,90 patients with T2 DM and CHD were selected as combined group and90 healthy subjects were selected as control group in Yancheng First People’s Hospital from January 2016 to June 2018.Serum concentrations of FSTL1,c Tn T and BNP of the three groups were tested.In combined group,serum concentra-tions of FSTL1,c Tn T and BNP were analyzed among different coronary lesions subgroups.Simple linear correlation andmultiple linear regression were used to analyze relationships between serum concentrations of FSTL1,c Tn T,BNP andGensini scores.ResultsSerum concentrations of triacylglycerol(TG),total cholesterol(TC),low-density lipoproteincholesterol(LDL-C),fasting blood glucose(FPG)of combined group and T2 DM group were significantly higher thanthose of control group(P<0.05).Serum concentration of high-density lipoprotein cholesterol(HDL-C)of combinedgroup and T2 DM group was significantly lower than that of control group(P<0.05).Serum concentrations of TG,TC,LDL-C and FPG of combined group were significantly higher than those of T2 DM group(P<0.05);Serum concentra-tion of HDL-C of combined group was significantly lower than that in T2 DM group(P<0.05).Serum concentrations ofFSTL1,c Tn T,BNP and Gensini scores of combined group and T2 DM group were significantly higher than those of con-trol group(P<0.05).Serum concentrations of FSTL1,c Tn,BNP and Gensini scores of combined group were signifi-cantly higher than those of T2 DM group(P<0.05).In combined group,serum concentrations of FSTL1,c Tn T andBNP in three vessel lesions subgroup and double vessel lesions subgroup were significantly higher than those in singlevessel lesion subgroup(P<0.05);serum concentration

关 键 词：冠状动脉疾病 2型糖尿病 卵泡抑素样蛋白-1 肌钙蛋白T B型钠尿肽 

分 类 号：R541.4[医药卫生—心血管疾病]